Injectable in situ forming microparticles: A novel drug delivery system

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dc.citation.epage318en_US
dc.citation.issueNumber2en_US
dc.citation.spage307en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorYapar, E. A.en_US
dc.contributor.authorInal, Ö.en_US
dc.contributor.authorÖzkan, Y.en_US
dc.contributor.authorBaykara, T.en_US
dc.date.accessioned2018-04-12T13:53:36Z
dc.date.available2018-04-12T13:53:36Z
dc.date.issued2012en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractPharmaceutical formulation research has recently been focusing on delivery systems which provide long therapeutic effects and reduced side effects, and involving simplified production stages and facilitated application process. In situ forming microparticle (ISM) systems, one of the latest approach in this field, offer a new encapsulation technique and meet the objectives stated above. Factors such as the carrier used to form the multiparticles, amount and type of drug and the vehicle type can be taken as the main performance criteria for these systems. Ongoing studies have shown that this new multiparticulate drug delivery system is suitable for achieving new implant delivery system with low risk of dose-dumping, capable of being modulated to exhibit varying release patterns, reproducible, easily applicable and welltolerated compared with classically surgical implants.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T13:53:36Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2012en
dc.identifier.doi10.4314/tjpr.v11i2.19en_US
dc.identifier.eissn1596-9827en_US
dc.identifier.issn1596-5996
dc.identifier.urihttp://hdl.handle.net/11693/38340
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.4314/tjpr.v11i2.19en_US
dc.source.titleTropical Journal of Pharmaceutical Researchen_US
dc.subjectControlled drug deliveryen_US
dc.subjectIn situ formingen_US
dc.subjectInjectableen_US
dc.subjectMicroparticle systemen_US
dc.subjectBupivacaineen_US
dc.subjectDiltiazemen_US
dc.subjectHaloperidolen_US
dc.subjectLeuprorelinen_US
dc.subjectMicrosphereen_US
dc.subjectMontelukasten_US
dc.subjectOilen_US
dc.subjectRisperidoneen_US
dc.subjectClinical effectivenessen_US
dc.subjectConcentration (parameters)en_US
dc.subjectControlled drug releaseen_US
dc.subjectDrug blood levelen_US
dc.subjectDrug delivery systemen_US
dc.subjectDrug efficacyen_US
dc.subjectDrug formulationen_US
dc.subjectDrug solubilityen_US
dc.subjectDrug stabilityen_US
dc.subjectDrug synthesisen_US
dc.subjectDrug tolerabilityen_US
dc.subjectHumanen_US
dc.subjectHydrophilicityen_US
dc.subjectHydrophobicityen_US
dc.subjectIn vitro studyen_US
dc.subjectIn vivo studyen_US
dc.subjectMaximum plasma concentrationen_US
dc.subjectMicroencapsulationen_US
dc.subjectNonhumanen_US
dc.subjectParticle sizeen_US
dc.subjectPhase separationen_US
dc.subjectProcess developmenten_US
dc.subjectReproducibilityen_US
dc.subjectReviewen_US
dc.subjectSurface propertyen_US
dc.subjectToxicity testingen_US
dc.titleInjectable in situ forming microparticles: A novel drug delivery systemen_US
dc.typeReviewen_US

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