PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus

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buir.contributor.authorJavili, Ali
dc.citation.epage32en_US
dc.citation.spage24en_US
dc.citation.volumeNumber99en_US
dc.contributor.authorSaeb, S.en_US
dc.contributor.authorSteinmann, P.en_US
dc.contributor.authorJavili, Alien_US
dc.date.accessioned2020-02-04T10:55:44Z
dc.date.available2020-02-04T10:55:44Z
dc.date.issued2019
dc.departmentDepartment of Mechanical Engineeringen_US
dc.description.abstractIn this manuscript, we employ interface enhanced computational homogenization to explore and detail on a number of unfamiliar characteristics that composites can exhibit at different length scales. Here, the interface between the constituents is general in the sense that both displacement and traction jumps across the interface are admissible. We carry out numerous computational investigations using the finite element method for a broad range of various material parameters. Our numerical results reveal that the effective response of a microstructure embedding general interfaces is intuitively unpredictable and highly complex. In particular, for certain ranges of material parameters the overall response shows insensitivity with respect to either microstructure size or stiffness-ratio between inclusion and matrix. This unique behavior is observed likewise for two- and three-dimensional unit-cells. Our findings provide a valuable guideline to design tunable composites utilizing interfaces.en_US
dc.description.provenanceSubmitted by Onur Emek (onur.emek@bilkent.edu.tr) on 2020-02-04T10:55:44Z No. of bitstreams: 1 Bilkent-research-paper.pdf: 268963 bytes, checksum: ad2e3a30c8172b573b9662390ed2d3cf (MD5)en
dc.description.provenanceMade available in DSpace on 2020-02-04T10:55:44Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 268963 bytes, checksum: ad2e3a30c8172b573b9662390ed2d3cf (MD5) Previous issue date: 2019en
dc.embargo.release2020-05-01
dc.identifier.doi10.1016/j.jaut.2019.01.004en_US
dc.identifier.issn0896-8411
dc.identifier.urihttp://hdl.handle.net/11693/53047
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.jaut.2019.01.004en_US
dc.source.titleJournal of Autoimmunityen_US
dc.subjectSLEen_US
dc.subjectTreatmenten_US
dc.subjectM2 macrophagesen_US
dc.subjectTLR2/1en_US
dc.subjectPAM3en_US
dc.subjectNZB/Wen_US
dc.titlePAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupusen_US
dc.typeArticleen_US

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