A microfluidic erythrocyte sedimentation rate analyzer using rouleaux formation kinetics

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dc.citation.epage11en_US
dc.citation.issueNumber3en_US
dc.citation.spage1en_US
dc.citation.volumeNumber21en_US
dc.contributor.authorIsiksacan, Z.en_US
dc.contributor.authorAsghari, M.en_US
dc.contributor.authorElbuken, C.en_US
dc.date.accessioned2018-04-12T10:37:31Z
dc.date.available2018-04-12T10:37:31Z
dc.date.issued2017-03en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractRed blood cell aggregation is an intrinsic property of red blood cells that form reversible stacked structures, also called rouleaux, under low shear rates. Erythrocyte sedimentation rate (ESR), commonly performed in clinics, is an indirect inflammation screener and a prognostic test for diseases. We have recently developed a microfluidic system for rapid measurement of ESR from 40 µl whole blood employing the aggregation dynamics. In this work, we propose the use of an aggregation inducer, dextran polyglucose, for the preparation of multiple blood samples with differing aggregation dynamics. Using these samples, we characterized the performance of the system with three aggregation indices and under varying experimental conditions. Additionally, using the same underlying principle, we improved the system for ESR measurement using both venipuncture and fingerprick whole blood samples depending on the user needs. The results demonstrate that the system performs equally well with both samples, which validates the compatibility of the system for both laboratory and point-of-care applications where venous and capillary blood are the primary samples, respectively. The detailed characterization presented in this study legitimates the feasibility of the system for ultrafast and facile measurement of ESR in clinics and diverse off-laboratory settings.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T10:37:31Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2017en
dc.identifier.doi10.1007/s10404-017-1878-7en_US
dc.identifier.issn1613-4982
dc.identifier.urihttp://hdl.handle.net/11693/36363
dc.language.isoEnglishen_US
dc.publisherSpringer Verlagen_US
dc.relation.isversionofhttps://doi.org/10.1007/s10404-017-1878-7en_US
dc.source.titleMicrofluidics and Nanofluidicsen_US
dc.subjectAggregationen_US
dc.subjectDextranen_US
dc.subjectErythrocyte sedimentation rate (ESR)en_US
dc.subjectMicrofluidicsen_US
dc.subjectPoint-of-careen_US
dc.subjectRed blood cellen_US
dc.subjectAgglomerationen_US
dc.subjectCellsen_US
dc.subjectDextranen_US
dc.subjectMicrofluidicsen_US
dc.subjectSedimentationen_US
dc.subjectAggregation dynamicsen_US
dc.subjectErythrocyte sedimentation rateen_US
dc.subjectExperimental conditionsen_US
dc.subjectMicro fluidic systemen_US
dc.subjectPoint of careen_US
dc.subjectRed blood cellen_US
dc.subjectRed blood cell aggregationen_US
dc.subjectUnderlying principlesen_US
dc.subjectBlooden_US
dc.titleA microfluidic erythrocyte sedimentation rate analyzer using rouleaux formation kineticsen_US
dc.typeArticleen_US

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