Impact of mesoporous silica nanoparticle surface functionality on hemolytic activity, thrombogenicity and non-specific protein adsorption

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buir.contributor.authorBayındır, Mehmet
dc.citation.epage1920en_US
dc.citation.issueNumber14en_US
dc.citation.spage1909en_US
dc.citation.volumeNumber1en_US
dc.contributor.authorYildirim, A.en_US
dc.contributor.authorOzgur E.en_US
dc.contributor.authorBayındır, Mehmeten_US
dc.date.accessioned2016-02-08T09:39:31Z
dc.date.available2016-02-08T09:39:31Z
dc.date.issued2013en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Physicsen_US
dc.description.abstractAlthough numerous mesoporous silica nanoparticle (MSN) drug carriers and theranostic agents with various surface functionalities have been designed in the last decade, their biocompatibility remains a matter of intensive debate. Here, we systematically evaluated interactions of a series of MSNs possessing different surface functional groups (ionic, polar, neutral, and hydrophobic) with blood constituents, in terms of their hemolytic activity, thrombogenicity, and adsorption of blood proteins on their surfaces. Using a hemolysis assay we showed that surface functionalization can reduce or even completely prevent the hemolytic activity of bare MSNs. We investigated thrombogenicity of MSNs by measuring prothrombin time (PT) and activated partial thromboplastin time (aPTT). We observed that none of the MSNs used in this study exhibit significant thrombogenic activity. Lastly, we examined non-specific protein adsorption on MSN surfaces using human serum albumin (HSA) and gamma globulins (γGs) and found that surface functionalization with ionic groups can greatly reduce protein adsorption. Demonstration of the surface functionalization having a crucial impact on blood compatibility might serve as a guideline for further investigation related to the design of mesoporous silica systems for biomedical applications, and shed light on research towards the ultimate goal of developing smart theranostic systems. © The Royal Society of Chemistry 2013.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:39:31Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2013en
dc.identifier.doi10.1039/c3tb20139ben_US
dc.identifier.eissn2050-7518
dc.identifier.issn2050-750X
dc.identifier.urihttp://hdl.handle.net/11693/21011
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c3tb20139ben_US
dc.source.titleJournal of Materials Chemistry Ben_US
dc.titleImpact of mesoporous silica nanoparticle surface functionality on hemolytic activity, thrombogenicity and non-specific protein adsorptionen_US
dc.typeArticleen_US

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