Cytotoxicity of multifunctional surfactant containing capped mesoporous silica nanoparticles

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buir.contributor.authorBayındır, Mehmet
dc.citation.epage32069en_US
dc.citation.issueNumber38en_US
dc.citation.spage32060en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorYildirim, A.en_US
dc.contributor.authorTurkaydin, M.en_US
dc.contributor.authorGaripcan, B.en_US
dc.contributor.authorBayındır, Mehmeten_US
dc.date.accessioned2018-04-12T10:48:31Z
dc.date.available2018-04-12T10:48:31Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractThis paper reports the synthesis of silica capped surfactant (cetyltrimethylammonium bromide; CTAB) and dye (Rose Bengal; RB) containing mesoporous silica nanoparticles (MSNs). Capping the pores of the surfactant containing MSNs with a thin silica layer decreased the immediate surfactant originated cytotoxicity of these particles without affecting their long term (3 days) cytotoxicity. Also, the silica capping process almost completely prevented the hemolytic activity of the surfactant containing MSNs. In addition, improved uptake of silica capped MSNs compared to the uncapped particles by cancer cells was demonstrated. The delayed cytotoxicity, low hemolytic activity, and better cellular uptake of the silica capped MSNs make them promising for the development of safe (i.e. with fewer side effects) yet efficient theranostic agents. These nanocarriers may release the loaded cytotoxic molecules (CTAB) mostly after being accumulated in the tumor site and cause so minimal damage to the normal tissues and blood components. In addition, the nanoscale confinement of RB molecules inside the pores of MSNs makes the particles brightly fluorescent. Furthermore, it was demonstrated that due to the singlet oxygen generation capability of the RB dye the silica capped MSNs can be also used for photodynamic therapy of cancer. © 2016 The Royal Society of Chemistry.en_US
dc.identifier.doi10.1039/c5ra21722aen_US
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/11693/36688
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1039/c5ra21722aen_US
dc.source.titleRSC Advancesen_US
dc.subjectDiseasesen_US
dc.subjectGas generatorsen_US
dc.subjectMoleculesen_US
dc.subjectNanoparticlesen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectSilicaen_US
dc.subjectSurface active agentsen_US
dc.subjectSynthesis (chemical)en_US
dc.subjectCapped mesoporous silicaen_US
dc.subjectCetyl trimethyl ammonium bromidesen_US
dc.subjectHemolytic activityen_US
dc.subjectLow hemolytic activitiesen_US
dc.subjectMesoporous silica nanoparticlesen_US
dc.subjectNano-scale confinementsen_US
dc.subjectSinglet oxygen generationen_US
dc.subjectTheranostic agentsen_US
dc.subjectCytotoxicityen_US
dc.titleCytotoxicity of multifunctional surfactant containing capped mesoporous silica nanoparticlesen_US
dc.typeArticleen_US

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