An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

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buir.contributor.authorYeşilgül, Nisa
buir.contributor.authorKılıç, Bilal
dc.citation.epage633en_US
dc.citation.issueNumber2en_US
dc.citation.spage624en_US
dc.citation.volumeNumber43en_US
dc.contributor.authorYeşilgül, Nisa
dc.contributor.authorKılıç, Bilal
dc.date.accessioned2020-10-22T11:29:41Z
dc.date.available2020-10-22T11:29:41Z
dc.date.issued2019
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractA series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted in spectacular bathochromic shifts (up to ~ 304 nm), and the projected photosensitizers had absorption bands in the therapeutic window of the electromagnetic spectrum (600–900 nm). The absorption maxima of compounds 4, 5, 6, and 7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed that compounds 6 and 7, with high singlet oxygen quantum yields (0.52 and 0.93, respectively), were excellent and promising candidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so far for BODIPY-based photosensitizers.en_US
dc.identifier.doi10.3906/kim-1810-26en_US
dc.identifier.eissn1303-6130
dc.identifier.issn1300-0527
dc.identifier.urihttp://hdl.handle.net/11693/54299
dc.language.isoEnglishen_US
dc.publisherTÜBİTAKen_US
dc.relation.isversionofhttps://doi.org/10.3906/kim-1810-26en_US
dc.source.titleTurkish Journal of Chemistryen_US
dc.subjectBODIPYen_US
dc.subjectPhotosensitizeren_US
dc.subjectPhotodynamic therapyen_US
dc.subjectSinglet oxygenen_US
dc.subjectNear-IR photosensitizeren_US
dc.titleAn exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapyen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Department of Chemistry