In vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flow

Simple item page
buir.contributor.authorIşıksaçan, Ziya
buir.contributor.authorSerhatlıoğlu, Murat
buir.contributor.authorElbüken, Çağlar
dc.citation.epage6005en_US
dc.citation.issueNumber18en_US
dc.citation.spage5996en_US
dc.citation.volumeNumber145en_US
dc.contributor.authorIşıksaçan, Ziya
dc.contributor.authorSerhatlıoğlu, Murat
dc.contributor.authorElbüken, Çağlar
dc.date.accessioned2021-02-26T19:04:00Z
dc.date.available2021-02-26T19:04:00Z
dc.date.issued2020-06
dc.description.abstractThe flow behavior of blood is determined mainly by red blood cell (RBC) deformation and aggregation as well as blood viscoelasticity. These intricately interdependent parameters should be monitored by healthcare providers to understand all aspects of circulatory flow dynamics under numerous cases including cardiovascular and infectious diseases. Current medical instruments and microfluidic systems lack the ability to quantify these parameters all at once and in physiologically relevant flow conditions. This work presents a handheld platform and a measurement method for quantitative analysis of multiple of these parameters from 50 μl undiluted blood inside a miniaturized channel. The assay is based on an optical transmission analysis of collective RBC deformation and aggregation under near-infrared illumination during a 1 s damped oscillatory flow and at stasis, respectively. Measurements with blood of different hemo-rheological properties demonstrate that the presented approach holds a potential for initiating simultaneous and routine on-chip blood flow analysis even in resource-poor settings.en_US
dc.identifier.doi10.1039/d0an00604aen_US
dc.identifier.issn0003-2654
dc.identifier.urihttp://hdl.handle.net/11693/75614
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://dx.doi.org/10.1039/d0an00604aen_US
dc.source.titleAnalysten_US
dc.titleIn vitro analysis of multiple blood flow determinants using red blood cell dynamics under oscillatory flowen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
In_vitro_analysis_of_multiple_blood_flow_determinants_using_red_blood_cell_dynamics_under_oscillatory_flow.pdf
Size:
4.98 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Institute of Materials Science and Nanotechnology (UNAM)