Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy

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dc.citation.epage840en_US
dc.citation.issueNumber4en_US
dc.citation.spage831en_US
dc.citation.volumeNumber204en_US
dc.contributor.authorSpisek, R.en_US
dc.contributor.authorKukreja, A.en_US
dc.contributor.authorChen, L. -C.en_US
dc.contributor.authorMatthews, P.en_US
dc.contributor.authorMazumder, A.en_US
dc.contributor.authorVesole, D.en_US
dc.contributor.authorJagannath, S.en_US
dc.contributor.authorZebroski, H. A.en_US
dc.contributor.authorSimpson, A. J. G.en_US
dc.contributor.authorRitter, G.en_US
dc.contributor.authorDurie, B.en_US
dc.contributor.authorCrowley, J.en_US
dc.contributor.authorShaughnessy, Jr. J.D.en_US
dc.contributor.authorScanlan, M. J.en_US
dc.contributor.authorGure, A. O.en_US
dc.contributor.authorBarlogie, B.en_US
dc.contributor.authorDhodapkar, M. V.en_US
dc.date.accessioned2016-02-08T10:14:36Z
dc.date.available2016-02-08T10:14:36Z
dc.date.issued2007en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractSpecific targets of cellular immunity in human premalignancy are largely unknown. Monoclonal gammopathy of undetermined significance (MGUS) represents a precursor lesion to myeloma (MM). We show that antigenic targets of spontaneous immunity in MGUS differ from MM. MGUS patients frequently mount a humoral and cellular immune response against SOX2, a gene critical for self-renewal in embryonal stem cells. Intranuclear expression of SOX2 marks the clonogenic CD138? compartment in MGUS. SOX2 expression is also detected in a proportion of CD138+ cells in MM patients. However, these patients lack anti-SOX2 immunity. Cellular immunity to SOX2 inhibits the clonogenic growth of MGUS cells in vitro. Detection of anti-SOX2 T cells predicts favorable clinical outcome in patients with asymptomatic plasmaproliferative disorders. Harnessing immunity to antigens expressed by tumor progenitor cells may be critical for prevention and therapy of human cancer.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:14:36Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2007en
dc.identifier.doi10.1084/jem.20062387en_US
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11693/23485
dc.language.isoEnglishen_US
dc.publisherRockefeller University Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1084/jem.20062387en_US
dc.source.titleJournal of Experimental Medicineen_US
dc.subjectSyndecan 1en_US
dc.subjectTranscription factor Sox2en_US
dc.subjectAdaptive immunityen_US
dc.subjectArticleen_US
dc.subjectCell growthen_US
dc.subjectCellular immunityen_US
dc.subjectControlled studyen_US
dc.subjectEmbryonic stem cellen_US
dc.subjectHumanen_US
dc.subjectHuman cellen_US
dc.subjectHuman tissueen_US
dc.subjectImmune responseen_US
dc.subjectMonoclonal immunoglobulinemiaen_US
dc.subjectMyelomaen_US
dc.subjectPriority journalen_US
dc.subjectProtein expressionen_US
dc.subjectBiological Markersen_US
dc.subjectCell Proliferationen_US
dc.subjectCells, cultureden_US
dc.subjectDisease progressionen_US
dc.subjectEmbryonic stem cellsen_US
dc.subjectHealthen_US
dc.subjectHMGB Proteinsen_US
dc.subjectHumansen_US
dc.subjectImmunoglobulin Gen_US
dc.subjectMultiple Myelomaen_US
dc.subjectNeoplasmsen_US
dc.subjectParaproteinemiasen_US
dc.subjectT-Lymphocytesen_US
dc.subjectTranscription Factorsen_US
dc.subjectTreatment Outcomeen_US
dc.titleFrequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathyen_US
dc.typeArticleen_US

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