Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy

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dc.citation.epage840
dc.citation.issueNumber4
dc.citation.spage831
dc.citation.volumeNumber204
dc.contributor.authorSpisek, R.
dc.contributor.authorKukreja, A.
dc.contributor.authorChen, L. -C.
dc.contributor.authorMatthews, P.
dc.contributor.authorMazumder, A.
dc.contributor.authorVesole, D.
dc.contributor.authorJagannath, S.
dc.contributor.authorZebroski, H. A.
dc.contributor.authorSimpson, A. J. G.
dc.contributor.authorRitter, G.
dc.contributor.authorDurie, B.
dc.contributor.authorCrowley, J.
dc.contributor.authorShaughnessy, Jr. J.D.
dc.contributor.authorScanlan, M. J.
dc.contributor.authorGure, A. O.
dc.contributor.authorBarlogie, B.
dc.contributor.authorDhodapkar, M. V.
dc.date.accessioned2016-02-08T10:14:36Z
dc.date.available2016-02-08T10:14:36Z
dc.date.issued2007
dc.departmentDepartment of Molecular Biology and Genetics
dc.description.abstractSpecific targets of cellular immunity in human premalignancy are largely unknown. Monoclonal gammopathy of undetermined significance (MGUS) represents a precursor lesion to myeloma (MM). We show that antigenic targets of spontaneous immunity in MGUS differ from MM. MGUS patients frequently mount a humoral and cellular immune response against SOX2, a gene critical for self-renewal in embryonal stem cells. Intranuclear expression of SOX2 marks the clonogenic CD138? compartment in MGUS. SOX2 expression is also detected in a proportion of CD138+ cells in MM patients. However, these patients lack anti-SOX2 immunity. Cellular immunity to SOX2 inhibits the clonogenic growth of MGUS cells in vitro. Detection of anti-SOX2 T cells predicts favorable clinical outcome in patients with asymptomatic plasmaproliferative disorders. Harnessing immunity to antigens expressed by tumor progenitor cells may be critical for prevention and therapy of human cancer.
dc.identifier.doi10.1084/jem.20062387
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11693/23485
dc.language.isoEnglish
dc.publisherRockefeller University Press
dc.relation.isversionofhttp://dx.doi.org/10.1084/jem.20062387
dc.source.titleJournal of Experimental Medicine
dc.subjectSyndecan 1
dc.subjectTranscription factor Sox2
dc.subjectAdaptive immunity
dc.subjectArticle
dc.subjectCell growth
dc.subjectCellular immunity
dc.subjectControlled study
dc.subjectEmbryonic stem cell
dc.subjectHuman
dc.subjectHuman cell
dc.subjectHuman tissue
dc.subjectImmune response
dc.subjectMonoclonal immunoglobulinemia
dc.subjectMyeloma
dc.subjectPriority journal
dc.subjectProtein expression
dc.subjectBiological Markers
dc.subjectCell Proliferation
dc.subjectCells, cultured
dc.subjectDisease progression
dc.subjectEmbryonic stem cells
dc.subjectHealth
dc.subjectHMGB Proteins
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectMultiple Myeloma
dc.subjectNeoplasms
dc.subjectParaproteinemias
dc.subjectT-Lymphocytes
dc.subjectTranscription Factors
dc.subjectTreatment Outcome
dc.titleFrequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy
dc.typeArticle

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