Electrospinning of polymer-free nanofibers from cyclodextrin inclusion complexes

Date
2011
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Langmuir
Print ISSN
0743-7463
Electronic ISSN
Publisher
American Chemical Society
Volume
27
Issue
10
Pages
6218 - 6226
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Series
Abstract

The electrospinning of polymer-free nanofibers from highly concentrated (160%, w/v) aqueous solutions of hydroxypropyl-β-cyclodextrin (HPβCD) and its inclusion complexes with triclosan (HPβCD/triclosan-IC) was achieved successfully. The dynamic light scattering (DLS) and rheology measurements indicated that the presence of considerable HPβCD aggregates and the high solution viscosity were the key factors in obtaining electrospun HPβCD and HPβCD/ triclosan-IC nanofibers without the use of any polymeric carrier. The HPβCD and HPβCD/triclosan-IC solutions containing 20% (w/w) urea yielded no fibers but only beads and splashes because of the depression of the self-aggregation of the HPβCD. The inclusion complexation of triclosan with HPβCD was studied by isothermal titration calorimetry (ITC) and turbidity measurements. The characteristics of the HPβCD and HPβCD/triclosan-IC nanofibers were investigated by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). It was found that the electrospinning of HPβCD/triclosan-IC solution having a 1:1 molar ratio was optimal for obtaining nanofibers without any uncomplexed guest molecules.

Course
Other identifiers
Book Title
Keywords
Nanofibers, Fibers, Urea, Molecules, Electrospinning
Citation
Published Version (Please cite this version)