Antibacterial nanofibers of pullulan/tetracycline-cyclodextrin inclusion complexes for fast-disintegrating oral drug delivery

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buir.contributor.authorDurgun, Engin
buir.contributor.orcidDurgun, Engin|0000-0002-0639-5862
dc.citation.epage333en_US
dc.citation.spage321en_US
dc.citation.volumeNumber610en_US
dc.contributor.authorHsiung, E.
dc.contributor.authorCelebioglu, A.
dc.contributor.authorChowdhury, R.
dc.contributor.authorKilic, M. E.
dc.contributor.authorDurgun, Engin
dc.contributor.authorAltier, C.
dc.contributor.authorUyar, T.
dc.date.accessioned2023-02-14T06:06:42Z
dc.date.available2023-02-14T06:06:42Z
dc.date.issued2021-12-08
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractTetracycline is a widely used antibiotic suffering from poor water solubility and low bioavailability. Here, hydroxypropyl-beta-cyclodextrin (HPβCD) was used to form inclusion complexes (IC) of tetracycline with 2:1 M ratio (CD:drug). Then, tetracycline-HPβCD-IC was mixed with pullulan- a non-toxic, water-soluble biopolymer - to form nanofibrous webs via electrospinning. The electrospinning of pullulan/tetracycline-HPβCD-IC was yielded into defect-free nanofibers collected in the form of a self-standing and flexible material with the loading capacity of ∼ 7.7 % (w/w). Pullulan/tetracycline nanofibers was also generated as control sample having the same drug loading. Tetracycline was found in the amorphous state in case of pullulan/tetracycline-HPβCD nanofibers due to inclusion complexation. Through inclusion complexation with HPβCD, enhanced aqueous solubility and faster release profile were provided for pullulan/tetracycline-HPβCD-IC nanofibers compared to pullulan/tetracycline one. Additionally, pullulan/tetracycline-HPβCD-IC nanofibers readily disintegrated when wetted with artificial saliva while pullulan/tetracycline nanofibers were not completely absorbed by the same simulate environment. Electrospun nanofibers showed promising antibacterial activity against both gram-positive and gram-negative bacteria. Briefly, our findings indicated that pullulan/tetracycline-HPβCD-IC nanofibers could be an attractive material as orally fast disintegrating drug delivery system for the desired antibiotic treatment thanks to its promising physicochemical and antibacterial properties.en_US
dc.description.provenanceSubmitted by Ezgi Uğurlu (ezgi.ugurlu@bilkent.edu.tr) on 2023-02-14T06:06:42Z No. of bitstreams: 1 Antibacterial_nanofibers_of_pullulantetracycline-cyclodextrin_inclusion_complexes_for_Fast-Disintegrating_oral_drug_delivery.pdf: 3957691 bytes, checksum: 3543437a96a9149928a0d45cfa89a983 (MD5)en
dc.description.provenanceMade available in DSpace on 2023-02-14T06:06:42Z (GMT). No. of bitstreams: 1 Antibacterial_nanofibers_of_pullulantetracycline-cyclodextrin_inclusion_complexes_for_Fast-Disintegrating_oral_drug_delivery.pdf: 3957691 bytes, checksum: 3543437a96a9149928a0d45cfa89a983 (MD5) Previous issue date: 2021-12-08en
dc.embargo.release2023-12-08
dc.identifier.doi10.1016/j.jcis.2021.12.013en_US
dc.identifier.eissn1095-7103
dc.identifier.issn0021-9797
dc.identifier.urihttp://hdl.handle.net/11693/111222
dc.language.isoEnglishen_US
dc.publisherElsevier Inc.en_US
dc.relation.isversionofhttps://doi.org/10.1016/j.jcis.2021.12.013en_US
dc.source.titleJournal of Colloid and Interface Scienceen_US
dc.subjectCyclodextrinen_US
dc.subjectElectrospinningen_US
dc.subjectNanofibersInclusion complexen_US
dc.subjectTetracyclineen_US
dc.subjectAntibioticen_US
dc.subjectFast disintegratingen_US
dc.subjectFast dissolvingen_US
dc.subjectOral drug deliveryen_US
dc.subjectAntibacterialen_US
dc.titleAntibacterial nanofibers of pullulan/tetracycline-cyclodextrin inclusion complexes for fast-disintegrating oral drug deliveryen_US
dc.typeArticleen_US

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