Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes

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dc.citation.epage141en_US
dc.citation.issueNumber1en_US
dc.citation.spage134en_US
dc.citation.volumeNumber38en_US
dc.contributor.authorAkturk, M.en_US
dc.contributor.authorAltinova, A.en_US
dc.contributor.authorMert I.en_US
dc.contributor.authorDincel, A.en_US
dc.contributor.authorSargin, A.en_US
dc.contributor.authorBuyukkagnici, U.en_US
dc.contributor.authorArslan, M.en_US
dc.contributor.authorDanisman, N.en_US
dc.date.accessioned2016-02-08T09:57:39Z
dc.date.available2016-02-08T09:57:39Z
dc.date.issued2010en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractAs shown in the previous studies, asymmetric dimethylarginine (ADMA) is related to endothelial dysfunction, whereas high-sensitive C-reactive protein (hCRP) is the marker of inflammation. In our study, we investigated ADMA, hCRP, and homocysteine concentrations in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during late pregnancy. Fifty-four women with GDM and 69 women with NGT between 32 and 39 weeks of gestation were included in this study. ADMA, hCRP, homocysteine, lipid parameters, glycated hemoglobin (HbA1c) levels, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured. The plasma ADMA concentrations were significantly higher in GDM patients than in NGT subjects (P = 0.03) and the hCRP levels were also significantly increased in GDM group when compared with those in the NGT group (P = 0.008). However, plasma homocysteine levels did not differ between the groups (P = 0.4), while HOMA-IR, insulin, and triglyceride levels were higher in the GDM group than in the NGT group (P = 0.001, 0.002, and 0.02, respectively). The ADMA concentrations in the third trimester were positively correlated with the glucose levels the 50-g glucose challenge test (GCT) during 24-28 weeks in the whole group (r = 0.21, P = 0.02). Our results demonstrate that ADMA and hCRP are elevated in women with GDM during late pregnancy. Further studies are needed to clarify the significance and the underlying mechanisms of the elevated ADMA and hCRP levels in women with GDM. © 2010 Springer Science+Business Media, LLC.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:57:39Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2010en
dc.identifier.doi10.1007/s12020-010-9361-1en_US
dc.identifier.issn1355008X
dc.identifier.urihttp://hdl.handle.net/11693/22260
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s12020-010-9361-1en_US
dc.source.titleEndocrineen_US
dc.subjectAsymmetric dimethylarginineen_US
dc.subjectGestational diabetesen_US
dc.subjectHigh-sensitive C-reactive protein (hCRP)en_US
dc.subjectHomocysteineen_US
dc.subjectInsulin resistanceen_US
dc.subjectC reactive proteinen_US
dc.subjectglucoseen_US
dc.subjectglycosylated hemoglobinen_US
dc.subjecthemoglobin A1cen_US
dc.subjecthomocysteineen_US
dc.subjectinsulinen_US
dc.subjectlipiden_US
dc.subjectn(g),n(g) dimethylarginineen_US
dc.subjecttriacylglycerolen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdiet therapyen_US
dc.subjectfemaleen_US
dc.subjectgestational ageen_US
dc.subjectglucose toleranceen_US
dc.subjecthemoglobin blood levelen_US
dc.subjecthumanen_US
dc.subjectinsulin blood levelen_US
dc.subjectinsulin resistanceen_US
dc.subjectinsulin treatmenten_US
dc.subjectlipid blood levelen_US
dc.subjectmajor clinical studyen_US
dc.subjectpregnancy diabetes mellitusen_US
dc.subjectpriority journalen_US
dc.subjectprotein blood levelen_US
dc.subjecttriacylglycerol blood levelen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectArginineen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectDiabetes, Gestationalen_US
dc.subjectFemaleen_US
dc.subjectHomocysteineen_US
dc.subjectHumansen_US
dc.subjectInsulin Resistanceen_US
dc.subjectPregnancyen_US
dc.subjectPregnancy Trimester, Thirden_US
dc.subjectYoung Adulten_US
dc.titleAsymmetric dimethylarginine concentrations are elevated in women with gestational diabetesen_US
dc.typeArticleen_US

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