Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes

Date
2010
Authors
Akturk, M.
Altinova, A.
Mert I.
Dincel, A.
Sargin, A.
Buyukkagnici, U.
Arslan, M.
Danisman, N.
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Supervisor
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Source Title
Endocrine
Print ISSN
1355008X
Electronic ISSN
Publisher
Volume
38
Issue
1
Pages
134 - 141
Language
English
Type
Article
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Abstract

As shown in the previous studies, asymmetric dimethylarginine (ADMA) is related to endothelial dysfunction, whereas high-sensitive C-reactive protein (hCRP) is the marker of inflammation. In our study, we investigated ADMA, hCRP, and homocysteine concentrations in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during late pregnancy. Fifty-four women with GDM and 69 women with NGT between 32 and 39 weeks of gestation were included in this study. ADMA, hCRP, homocysteine, lipid parameters, glycated hemoglobin (HbA1c) levels, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured. The plasma ADMA concentrations were significantly higher in GDM patients than in NGT subjects (P = 0.03) and the hCRP levels were also significantly increased in GDM group when compared with those in the NGT group (P = 0.008). However, plasma homocysteine levels did not differ between the groups (P = 0.4), while HOMA-IR, insulin, and triglyceride levels were higher in the GDM group than in the NGT group (P = 0.001, 0.002, and 0.02, respectively). The ADMA concentrations in the third trimester were positively correlated with the glucose levels the 50-g glucose challenge test (GCT) during 24-28 weeks in the whole group (r = 0.21, P = 0.02). Our results demonstrate that ADMA and hCRP are elevated in women with GDM during late pregnancy. Further studies are needed to clarify the significance and the underlying mechanisms of the elevated ADMA and hCRP levels in women with GDM. © 2010 Springer Science+Business Media, LLC.

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Keywords
Asymmetric dimethylarginine, Gestational diabetes, High-sensitive C-reactive protein (hCRP), Homocysteine, Insulin resistance, C reactive protein, glucose, glycosylated hemoglobin, hemoglobin A1c, homocysteine, insulin, lipid, n(g),n(g) dimethylarginine, triacylglycerol, adult, article, controlled study, diet therapy, female, gestational age, glucose tolerance, hemoglobin blood level, human, insulin blood level, insulin resistance, insulin treatment, lipid blood level, major clinical study, pregnancy diabetes mellitus, priority journal, protein blood level, triacylglycerol blood level, Adolescent, Adult, Arginine, C-Reactive Protein, Diabetes, Gestational, Female, Homocysteine, Humans, Insulin Resistance, Pregnancy, Pregnancy Trimester, Third, Young Adult
Citation
Published Version (Please cite this version)