A retrospective comparison of allogeneic peripheral blood stem cell and bone marrow transplantation results from a single center: a focus on the incidence of graft-vs.-host disease and relapse

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dc.citation.epage35en_US
dc.citation.issueNumber1en_US
dc.citation.spage28en_US
dc.citation.volumeNumber5en_US
dc.contributor.authorÜstün, C.en_US
dc.contributor.authorArslan, Ö.en_US
dc.contributor.authorBeksaç, M.en_US
dc.contributor.authorKoç, H.en_US
dc.contributor.authorGürman, G.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.contributor.authorYilmaz, B.en_US
dc.contributor.authorİlban, O.en_US
dc.contributor.authorAkan, H.en_US
dc.contributor.authorÖzcan, M.en_US
dc.contributor.authorDemirer, T.en_US
dc.contributor.authorUysal, A.en_US
dc.contributor.authorKonuk, N.en_US
dc.contributor.authorArat, M.en_US
dc.contributor.authorDilek, İ.en_US
dc.contributor.authorÇelebi, H.en_US
dc.contributor.authorCoskun, H. S.en_US
dc.date.accessioned2016-02-08T10:39:31Z
dc.date.available2016-02-08T10:39:31Z
dc.date.issued1999en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractTo detect the effect of the stem cell source, allogeneic peripheral blood stem cell transplantations (alloPBSCTs) performed between 1995 and 1997 from human leukocyte antigen (HLA)-identical siblings in 40 patients with acute and chronic hematological disorders were compared with a historical group of 40 patients with similar variables who had received allogeneic bone marrow transplants (alloBMTs) between 1993 and 1995. Patients in both groups were identical except that both the recipient and the donor ages were, on average, higher in the alloPBSCT group (26 vs. 36 [p = 0.005] and 27 vs. 32 [p = 0.024], respectively). Patients received similar therapy excluding posttransplant granulocyte colony-stimulating factor administration (97% in alloBMT vs. 12.5% in alloPBSCT). The median time to reach neutrophil counts >0.5×109/L and platelet counts >20×109/L was 13 and 14 days, respectively, in patients receiving alloPBSCTs compared with 19 and 27 days in patients receiving alloBMTs (p = 0.0014 and p = 0.0002). The alloPBSCT group required similar transfusions of red blood cells or platelets. The incidence of grade II-IV acute graft-vs.-host disease (aGVHD) was similar in both groups. However, chronic GVHD (cGVHD) of all grades developed in 78.1% of patients in the alloPBSCT group after a median follow-up period of 12.5 (range 0.5-34) months. In alloBMT recipients, cGVHD of all grades developed in 21.4% after a median follow-up period of 38 (range 0.5-62) months (p = 0.00001). Day 100 transplant-related mortality was also similar: 20% (8 of 40) in the alloBMT patients and 17.5% (7 of 40) in the alloPBSCT group. Although not statistically significant, a relatively higher relapse rate occurred in the alloBMT group (21.4 vs. 10.7%). The estimated disease-free survival in month 24 was 51.3% for alloBMT and 54.6% for alloPBSCT, and the estimated overall survival in month 24 was 56.1% for alloBMT and 64.6% for alloPBSCT. In conclusion, this retrospective comparison suggests that alloPBSCT from HLA-identical donors is associated with faster engraftment, fewer transfusions, and no greater incidence of aGVHD, but a high incidence of cGVHD.en_US
dc.identifier.issn1083-8791
dc.identifier.urihttp://hdl.handle.net/11693/25127
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.source.titleBiology of Blood and Marrow Transplantationen_US
dc.subjectBone marrowen_US
dc.subjectPeripheral stem cellen_US
dc.subjectTransplantationen_US
dc.subjectAcute nonlymphocytic leukemiaen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAllotransplantationen_US
dc.subjectBone marrow transplantationen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectComparative studyen_US
dc.subjectFemaleen_US
dc.subjectGraft rejectionen_US
dc.subjectGraft versus host reactionen_US
dc.subjectHematopoietic stem cell transplantationen_US
dc.subjectHumanen_US
dc.subjectIncidenceen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectOpportunistic infectionen_US
dc.subjectRecurrent diseaseen_US
dc.subjectRetrospective studyen_US
dc.subjectTreatment outcomeen_US
dc.subjectTurkey (republic)en_US
dc.subjectHumansen_US
dc.subjectLeukemia, myeloid, chronicen_US
dc.subjectLeukemia, nonlymphocytic, acuteen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectOpportunistic infectionsen_US
dc.subjectRecurrenceen_US
dc.subjectRetrospective studiesen_US
dc.subjectTransplantation, homologousen_US
dc.subjectTreatment outcomeen_US
dc.subjectTurkeyen_US
dc.titleA retrospective comparison of allogeneic peripheral blood stem cell and bone marrow transplantation results from a single center: a focus on the incidence of graft-vs.-host disease and relapseen_US
dc.typeArticleen_US

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