Designing excited states: theory-guided access to efficient photosensitizers for photodynamic action

Date
2011
Authors
Cakmak, Y.
Kolemen, S.
Duman, S.
Dede, Y.
Dolen, Y.
Kilic, B.
Kostereli, Z.
Yildirim, L. T.
Dogan, A. L.
Guc, D.
Advisor
Instructor
Source Title
Angewandte Chemie - International Edition
Print ISSN
1433-7851
Electronic ISSN
1521-3773
Publisher
Volume
50
Issue
50
Pages
11937 - 11941
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

The in silico design of tetraradical S 1 states was validated experimentally through synthesis, followed by characterization including phosphorescence measurements, use of trap molecules, and cell culture studies, leading to a series of orthogonal dimers of Bodipy chromophores with remarkable singlet oxygen efficiencies (see picture). A new path for the rational development of efficient photosensitizers is thus revealed.

Course
Other identifiers
Book Title
Keywords
Bodipy dyes, Fluorescence, Photodynamic therapy, Sensitizers, Singlet oxygen
Citation
Published Version (Please cite this version)