A portable microfluidic system for rapid measurement of the erythrocyte sedimentation rate

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dc.citation.epage4690en_US
dc.citation.issueNumber24en_US
dc.citation.spage4682en_US
dc.citation.volumeNumber16en_US
dc.contributor.authorIsiksacan, Z.en_US
dc.contributor.authorErel, O.en_US
dc.contributor.authorElbuken, C.en_US
dc.date.accessioned2018-04-12T10:48:12Z
dc.date.available2018-04-12T10:48:12Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractThe erythrocyte sedimentation rate (ESR) is a frequently used 30 min or 60 min clinical test for screening of several inflammatory conditions, infections, trauma, and malignant diseases, as well as non-inflammatory conditions including prostate cancer and stroke. Erythrocyte aggregation (EA) is a physiological process where erythrocytes form face-to-face linear structures, called rouleaux, at stasis or low shear rates. In this work, we proposed a method for ESR measurement from EA. We developed a microfluidic opto-electro-mechanical system, using which we experimentally showed a significant correlation (R2 = 0.86) between ESR and EA. The microfluidic system was shown to measure ESR from EA using fingerprick blood in 2 min. 40 μl of whole blood is filled in a disposable polycarbonate cartridge which is illuminated with a near infrared emitting diode. Erythrocytes were disaggregated under the effect of a mechanical shear force using a solenoid pinch valve. Following complete disaggregation, transmitted light through the cartridge was measured using a photodetector for 1.5 min. The intensity level is at its lowest at complete disaggregation and highest at complete aggregation. We calculated ESR from the transmitted signal profile. We also developed another microfluidic cartridge specifically for monitoring the EA process in real-time during ESR measurement. The presented system is suitable for ultrafast, low-cost, and low-sample volume measurement of ESR at the point-of-care.en_US
dc.identifier.doi10.1039/C6LC01036Aen_US
dc.identifier.issn1473-0197
dc.identifier.urihttp://hdl.handle.net/11693/36679
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/C6LC01036Aen_US
dc.source.titleLab on a Chipen_US
dc.subjectPolycarbonateen_US
dc.subjectBlood samplingen_US
dc.subjectCalculationen_US
dc.subjectErythrocyte aggregationen_US
dc.subjectErythrocyte sedimentation rateen_US
dc.subjectForceen_US
dc.subjectHumanen_US
dc.subjectLight emitting diodeen_US
dc.subjectMeasurement accuracyen_US
dc.subjectMeasurement repeatabilityen_US
dc.subjectMicrofluidicsen_US
dc.subjectPoint of care systemen_US
dc.subjectPortable equipmenten_US
dc.subjectPriority journalen_US
dc.subjectShear rateen_US
dc.titleA portable microfluidic system for rapid measurement of the erythrocyte sedimentation rateen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)