Focusing-free impedimetric differentiation of red blood cells and leukemia cells: a system optimization
buir.contributor.author | Serhatlıoğlu, Murat | |
buir.contributor.author | Elbüken, Çağlar | |
dc.citation.epage | 10 | en_US |
dc.citation.spage | 1 | en_US |
dc.citation.volumeNumber | 307 | en_US |
dc.contributor.author | Bilican, İ. | |
dc.contributor.author | Güler, M. T. | |
dc.contributor.author | Serhatlıoğlu, Murat | |
dc.contributor.author | Kırındı, T. | |
dc.contributor.author | Elbüken, Çağlar | |
dc.date.accessioned | 2021-03-05T06:17:42Z | |
dc.date.available | 2021-03-05T06:17:42Z | |
dc.date.issued | 2020 | |
dc.department | Institute of Materials Science and Nanotechnology (UNAM) | en_US |
dc.description.abstract | A focusing-free microfluidic impedimetric cell detection system is developed. The effect of the channel dimensions, solution conductivity, excitation voltage, and particle size on impedimetric signal outputs were optimized to increase the sensitivity of the system. Conventional microfabrication techniques were adapted to obtain low height, resealable microchannels. The geometry optimization was performed by a combination of analytical, numerical and experimental approaches. The results demonstrate that reliable impedimetric particle differentiation can be achieved without any labeling or particle focusing. The system parameters were studied and rule-of-thumb design criteria were provided. Finally, using the developed system, red blood cells and leukemia cells were experimentally detected and differentiated. Thanks to its simplicity, the focusing-free cell differentiation system may find applications in several cellular diagnostic uses. | en_US |
dc.description.provenance | Submitted by Zeynep Aykut (zeynepay@bilkent.edu.tr) on 2021-03-05T06:17:42Z No. of bitstreams: 1 Focusing_free_impedimetric_differentiation_of_red_blood_cells_and_leukemia_cells_a_system_optimization.pdf: 4134504 bytes, checksum: a52b0baa24de3821f1ac45e92c201382 (MD5) | en |
dc.description.provenance | Made available in DSpace on 2021-03-05T06:17:42Z (GMT). No. of bitstreams: 1 Focusing_free_impedimetric_differentiation_of_red_blood_cells_and_leukemia_cells_a_system_optimization.pdf: 4134504 bytes, checksum: a52b0baa24de3821f1ac45e92c201382 (MD5) Previous issue date: 2020 | en |
dc.embargo.release | 2022-03-15 | |
dc.identifier.doi | 10.1016/j.snb.2019.127531 | en_US |
dc.identifier.issn | 0925-4005 | |
dc.identifier.uri | http://hdl.handle.net/11693/75810 | |
dc.language.iso | English | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | https://dx.doi.org/10.1016/j.snb.2019.127531 | en_US |
dc.source.title | Sensors and Actuators, B: Chemical | en_US |
dc.subject | Impedance spectroscopy | en_US |
dc.subject | Red blood cell | en_US |
dc.subject | White blood cell | en_US |
dc.subject | Leukemia | en_US |
dc.subject | Microfluidic flow cytometry | en_US |
dc.title | Focusing-free impedimetric differentiation of red blood cells and leukemia cells: a system optimization | en_US |
dc.type | Article | en_US |
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