A bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of light
dc.citation.epage | 2878 | en_US |
dc.citation.issueNumber | 8 | en_US |
dc.citation.spage | 2875 | en_US |
dc.citation.volumeNumber | 55 | en_US |
dc.contributor.author | Turan, I. S. | en_US |
dc.contributor.author | Yildiz, D. | en_US |
dc.contributor.author | Turksoy, A. | en_US |
dc.contributor.author | Gunaydin, G. | en_US |
dc.contributor.author | Akkaya, E. U. | en_US |
dc.date.accessioned | 2018-04-12T10:58:44Z | |
dc.date.available | 2018-04-12T10:58:44Z | |
dc.date.issued | 2016 | en_US |
dc.department | Institute of Materials Science and Nanotechnology (UNAM) | en_US |
dc.department | Department of Chemistry | en_US |
dc.description.abstract | The photosensitized generation of singlet oxygen within tumor tissues during photodynamic therapy (PDT) is self-limiting, as the already low oxygen concentrations within tumors is further diminished during the process. In certain applications, to minimize photoinduced hypoxia the light is introduced intermittently (fractional PDT) to allow time for the replenishment of cellular oxygen. This condition extends the time required for effective therapy. Herein, we demonstrated that a photosensitizer with an additional 2-pyridone module for trapping singlet oxygen would be useful in fractional PDT. Thus, in the light cycle, the endoperoxide of 2-pyridone is generated along with singlet oxygen. In the dark cycle, the endoperoxide undergoes thermal cycloreversion to produce singlet oxygen, regenerating the 2-pyridone module. As a result, the photodynamic process can continue in the dark as well as in the light cycles. Cell-culture studies validated this working principle in vitro. | en_US |
dc.description.provenance | Made available in DSpace on 2018-04-12T10:58:44Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2016 | en |
dc.identifier.doi | 10.1002/anie.201511345 | en_US |
dc.identifier.eissn | 1521-3773 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.uri | http://hdl.handle.net/11693/36967 | |
dc.language.iso | English | en_US |
dc.publisher | Wiley-VCH Verlag | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1002/anie.201511345 | en_US |
dc.source.title | Angewandte Chemie - International Edition | en_US |
dc.subject | Cell culture | en_US |
dc.subject | Gas generators | en_US |
dc.subject | Oxygen | en_US |
dc.subject | Peroxides | en_US |
dc.subject | Photochemical reactions | en_US |
dc.subject | Photosensitizers | en_US |
dc.subject | Tumors | en_US |
dc.subject | BODIPY | en_US |
dc.subject | Cellular oxygen | en_US |
dc.subject | Cycloreversion | en_US |
dc.subject | Effective therapy | en_US |
dc.subject | Photodynamic process | en_US |
dc.subject | Photodynamic therapy (PDT) | en_US |
dc.subject | Singlet oxygen | en_US |
dc.subject | Singlet oxygen generation | en_US |
dc.subject | Photodynamic therapy | en_US |
dc.subject | Light | en_US |
dc.subject | Photochemotherapy | en_US |
dc.subject | Photosensitizing Agents | en_US |
dc.subject | Proton Magnetic Resonance Spectroscopy | en_US |
dc.subject | Singlet Oxygen | en_US |
dc.title | A bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of light | en_US |
dc.type | Article | en_US |
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