A bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of light

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dc.citation.epage2878en_US
dc.citation.issueNumber8en_US
dc.citation.spage2875en_US
dc.citation.volumeNumber55en_US
dc.contributor.authorTuran, I. S.en_US
dc.contributor.authorYildiz, D.en_US
dc.contributor.authorTurksoy, A.en_US
dc.contributor.authorGunaydin, G.en_US
dc.contributor.authorAkkaya, E. U.en_US
dc.date.accessioned2018-04-12T10:58:44Z
dc.date.available2018-04-12T10:58:44Z
dc.date.issued2016en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Chemistryen_US
dc.description.abstractThe photosensitized generation of singlet oxygen within tumor tissues during photodynamic therapy (PDT) is self-limiting, as the already low oxygen concentrations within tumors is further diminished during the process. In certain applications, to minimize photoinduced hypoxia the light is introduced intermittently (fractional PDT) to allow time for the replenishment of cellular oxygen. This condition extends the time required for effective therapy. Herein, we demonstrated that a photosensitizer with an additional 2-pyridone module for trapping singlet oxygen would be useful in fractional PDT. Thus, in the light cycle, the endoperoxide of 2-pyridone is generated along with singlet oxygen. In the dark cycle, the endoperoxide undergoes thermal cycloreversion to produce singlet oxygen, regenerating the 2-pyridone module. As a result, the photodynamic process can continue in the dark as well as in the light cycles. Cell-culture studies validated this working principle in vitro.en_US
dc.identifier.doi10.1002/anie.201511345en_US
dc.identifier.eissn1521-3773
dc.identifier.issn1433-7851
dc.identifier.urihttp://hdl.handle.net/11693/36967
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201511345en_US
dc.source.titleAngewandte Chemie - International Editionen_US
dc.subjectCell cultureen_US
dc.subjectGas generatorsen_US
dc.subjectOxygenen_US
dc.subjectPeroxidesen_US
dc.subjectPhotochemical reactionsen_US
dc.subjectPhotosensitizersen_US
dc.subjectTumorsen_US
dc.subjectBODIPYen_US
dc.subjectCellular oxygenen_US
dc.subjectCycloreversionen_US
dc.subjectEffective therapyen_US
dc.subjectPhotodynamic processen_US
dc.subjectPhotodynamic therapy (PDT)en_US
dc.subjectSinglet oxygenen_US
dc.subjectSinglet oxygen generationen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectLighten_US
dc.subjectPhotochemotherapyen_US
dc.subjectPhotosensitizing Agentsen_US
dc.subjectProton Magnetic Resonance Spectroscopyen_US
dc.subjectSinglet Oxygenen_US
dc.titleA bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of lighten_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Department of Chemistry