Hierarchical self-assembly of histidine-functionalized peptide amphiphiles into supramolecular chiral nanostructures

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage7956en_US
dc.citation.issueNumber32en_US
dc.citation.spage7947en_US
dc.citation.volumeNumber33en_US
dc.contributor.authorKoc, M. H.en_US
dc.contributor.authorCiftci, G. C.en_US
dc.contributor.authorBaday, S.en_US
dc.contributor.authorCastelletto, V.en_US
dc.contributor.authorHamley, I. W.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2018-04-12T11:08:50Z
dc.date.available2018-04-12T11:08:50Z
dc.date.issued2017en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractControlling the hierarchical organization of self-assembling peptide amphiphiles into supramolecular nanostructures opens up the possibility of developing biocompatible functional supramolecular materials for various applications. In this study, we show that the hierarchical self-assembly of histidine- (His-) functionalized PAs containing d- or l-amino acids can be controlled by both solution pH and molecular chirality of the building blocks. An increase in solution pH resulted in the structural transition of the His-functionalized chiral PA assemblies from nanosheets to completely closed nanotubes through an enhanced hydrogen-bonding capacity and π-π stacking of imidazole ring. The effects of the stereochemistry and amino acid sequence of the PA backbone on the supramolecular organization were also analyzed by CD, TEM, SAXS, and molecular dynamics simulations. In addition, an investigation of chiral mixtures revealed the differences between the hydrogen-bonding capacities and noncovalent interactions of PAs with d- and l-amino acids.en_US
dc.description.provenanceMade available in DSpace on 2018-04-12T11:08:50Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 179475 bytes, checksum: ea0bedeb05ac9ccfb983c327e155f0c2 (MD5) Previous issue date: 2017en
dc.identifier.doi10.1021/acs.langmuir.7b01266en_US
dc.identifier.issn0743-7463
dc.identifier.urihttp://hdl.handle.net/11693/37290
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acs.langmuir.7b01266en_US
dc.source.titleLangmuiren_US
dc.subjectAmino acidsen_US
dc.subjectAmphiphilesen_US
dc.subjectBiocompatibilityen_US
dc.subjectBiological materialsen_US
dc.subjectHydrogen bondsen_US
dc.subjectIonsen_US
dc.subjectMolecular dynamicsen_US
dc.subjectNanostructuresen_US
dc.subjectPeptidesen_US
dc.subjectPolypeptidesen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectYarnen_US
dc.subjectHierarchical organizationsen_US
dc.subjectHierarchical self-assemblyen_US
dc.subjectMolecular dynamics simulationsen_US
dc.subjectNon-covalent interactionen_US
dc.subjectSelf-assembling peptidesen_US
dc.subjectSupra-molecular nano structuresen_US
dc.subjectSupramolecular materialsen_US
dc.subjectSupramolecular organizationsen_US
dc.subjectSelf assemblyen_US
dc.titleHierarchical self-assembly of histidine-functionalized peptide amphiphiles into supramolecular chiral nanostructuresen_US
dc.typeArticleen_US

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