Therapeutic nanomaterials for cartilage regeneration

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buir.contributor.authorGüler, Mustafa O.
dc.citation.epage85en_US
dc.citation.spage59en_US
dc.contributor.authorArslan, Elifen_US
dc.contributor.authorÜstün Yaylacı, Seheren_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, Ayşe B.en_US
dc.contributor.editorGüler, Mustafa O.
dc.contributor.editorTekinay, Ayşe B.
dc.date.accessioned2019-04-22T11:11:03Z
dc.date.available2019-04-22T11:11:03Z
dc.date.issued2016-03-11en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.descriptionChapter 4en_US
dc.description.abstractArticular cartilage (AC) is the main focus of this chapter and indeed most cartilage regeneration studies, since it is commonly affected by diseases and traumatic injuries that necessitate its therapeutic regeneration. There are four main approaches for cartilage regeneration: cultured cell implantation, engineered tissue construct implantation, scaffoldless tissue regeneration, and guided tissue regeneration. Cartilage growth, development, and repair are dependent on both biomechanical and biological signals. The most important growth factors used in cartilage regeneration and tissue engineering approaches are the transforming growth factor ß (TGF‐ß) family members, particularly TGF‐ß1 and TGF‐ß3. Overall, new strategies in the field of cartilage regeneration focus on the unique biochemical and physical properties of native cartilage to design novel tissue constructs that are decorated with cartilage‐specific signals and display suitable anatomical geometries and mechanical properties for the treatment of large tissue defects.en_US
dc.description.provenanceSubmitted by Taner Korkmaz (tanerkorkmaz@bilkent.edu.tr) on 2019-04-22T11:11:03Z No. of bitstreams: 1 Therapeutic_Nanomaterials_for_Cartilage_Regeneration.pdf: 109358 bytes, checksum: 52a850dc6a96af6c908dde63aec62a7e (MD5)en
dc.description.provenanceMade available in DSpace on 2019-04-22T11:11:03Z (GMT). No. of bitstreams: 1 Therapeutic_Nanomaterials_for_Cartilage_Regeneration.pdf: 109358 bytes, checksum: 52a850dc6a96af6c908dde63aec62a7e (MD5) Previous issue date: 2016-03-11en
dc.identifier.doi10.1002/9781118987483.ch4en_US
dc.identifier.doi10.1002/9781118987483en_US
dc.identifier.eisbn9781118987483
dc.identifier.isbn9781118987452
dc.identifier.urihttp://hdl.handle.net/11693/50875
dc.language.isoEnglishen_US
dc.publisherJohn Wiley & Sonsen_US
dc.relation.ispartofTherapeutic nanomaterialsen_US
dc.relation.isversionofhttps://doi.org/10.1002/9781118987483.ch4en_US
dc.relation.isversionofhttps://doi.org/10.1002/9781118987483en_US
dc.subjectCartilage growthen_US
dc.subjectCartilage regenerationen_US
dc.subjectCultured cell implantationen_US
dc.subjectEngineered tissue construct implantationen_US
dc.subjectGuided tissue regenerationen_US
dc.subjectScaffoldless tissue regenerationen_US
dc.subjectTherapeutic nanomaterialsen_US
dc.subjectTissue engineeringen_US
dc.titleTherapeutic nanomaterials for cartilage regenerationen_US
dc.typeBook Chapteren_US

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Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)