Na+/I-symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormones

Simple item page
dc.citation.epage344en_US
dc.citation.issueNumber3en_US
dc.citation.spage338en_US
dc.citation.volumeNumber154en_US
dc.contributor.authorAkturk, M.en_US
dc.contributor.authorOruc, A.S.en_US
dc.contributor.authorDanisman, N.en_US
dc.contributor.authorErkek, S.en_US
dc.contributor.authorBuyukkagnici, U.en_US
dc.contributor.authorUnlu, E.en_US
dc.contributor.authorTazebay, U.H.en_US
dc.date.accessioned2016-02-08T09:36:11Z
dc.date.available2016-02-08T09:36:11Z
dc.date.issued2013en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractPlacental type 3 iodothyronine deiodinase (D3) potentially protects the fetus from the elevated maternal thyroid hormones. Na+/I- symporter (NIS) is a plasma membrane glycoprotein, which mediates active iodide uptake. Our objectives were to establish the distribution of NIS and D3 gene expressions in the placenta and the amniotic membrane and to investigate the relationship between placental D3 and NIS gene expressions and maternal iodine, selenium, and thyroid hormone status. Thyroid hormones, urinary iodine concentration (UIC), and selenium levels were measured in 49 healthy term pregnant women. NIS and D3 gene expressions were studied with the total mRNA RT-PCR method in tissues from maternal placenta (n = 49), fetal placenta (n = 9), and amniotic membrane (n = 9). NIS and D3 gene expressions were shown in the fetal and maternal sides of the placenta and amniotic membrane. Mean blood selenium level was 66 ± 26.5 μg/l, and median UIC was 143 μg/l. We could not demonstrate any statistically significant relationship of spot UIC and blood selenium with NIS and D3 expression (p > 0.05). Positive correlations were found between NIS and thyroxine-binding globulin (TBG) (r = 0.3, p = 0.042) and between D3 and preoperative glucose levels (r = 0.4, p = 0.006). D3 and NIS genes are expressed in term placenta and amniotic membrane; thus, in addition to placenta, amniotic membrane contributes to regulation of maternofetal iodine and thyroid hormone transmission. Further studies are needed to clarify the relationship between maternal glucose levels and placental D3 expression and between TBG and placental NIS expression. © 2013 Springer Science+Business Media New York.en_US
dc.identifier.doi10.1007/s12011-013-9748-yen_US
dc.identifier.issn1634984
dc.identifier.urihttp://hdl.handle.net/11693/20834
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s12011-013-9748-yen_US
dc.source.titleBiological Trace Element Researchen_US
dc.subjectAmniotic membraneen_US
dc.subjectIodineen_US
dc.subjectNa+/I- symporteren_US
dc.subjectPlacentaen_US
dc.subjectSeleniumen_US
dc.subjectType 3 iodothyronine deiodinaseen_US
dc.subjectglucoseen_US
dc.subjectinsulinen_US
dc.subjectiodineen_US
dc.subjectliothyronineen_US
dc.subjectmessenger RNAen_US
dc.subjectprealbuminen_US
dc.subjectseleniumen_US
dc.subjectsodium iodide symporteren_US
dc.subjectthyroid hormoneen_US
dc.subjectthyrotropinen_US
dc.subjectthyroxineen_US
dc.subjectthyroxine binding globulinen_US
dc.subjectthyroxine deiodinaseen_US
dc.subjectadulten_US
dc.subjectamnionen_US
dc.subjectanalytical equipmenten_US
dc.subjectarticleen_US
dc.subjectatomic absorption spectrometryen_US
dc.subjectblood levelen_US
dc.subjectcesarean sectionen_US
dc.subjectcorrelation analysisen_US
dc.subjectechographen_US
dc.subjectechographyen_US
dc.subjectfemaleen_US
dc.subjectgene expressionen_US
dc.subjectglucose blood levelen_US
dc.subjecthumanen_US
dc.subjectimmunoradiometric assayen_US
dc.subjectnormal humanen_US
dc.subjectplacentaen_US
dc.subjectpreoperative evaluationen_US
dc.subjectradioimmunoassayen_US
dc.subjectreverse transcription polymerase chain reactionen_US
dc.subjectspectrometeren_US
dc.subjecturinalysisen_US
dc.subjectvolunteeren_US
dc.subjectAdulten_US
dc.subjectAmnionen_US
dc.subjectFemaleen_US
dc.subjectGene Expression Regulation, Developmentalen_US
dc.subjectGestational Ageen_US
dc.subjectHumansen_US
dc.subjectIodide Peroxidaseen_US
dc.subjectIodineen_US
dc.subjectPlacentaen_US
dc.subjectPregnancyen_US
dc.subjectReverse Transcriptase Polymerase Chain Reactionen_US
dc.subjectSeleniumen_US
dc.subjectSymportersen_US
dc.subjectThyroid Hormonesen_US
dc.subjectThyroxine-Binding Globulinen_US
dc.titleNa+/I-symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormonesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Na+I- symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormones.pdf
Size:
253.07 KB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download

Collections

Department of Molecular Biology and Genetics