In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction

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buir.contributor.authorAtalar, Ergin
dc.citation.epage2293en_US
dc.citation.issueNumber18en_US
dc.citation.spage2290en_US
dc.citation.volumeNumber107en_US
dc.contributor.authorKraitchman, D. L.en_US
dc.contributor.authorHeldman, A. W.en_US
dc.contributor.authorAtalar, Erginen_US
dc.contributor.authorAmado, L. C.en_US
dc.contributor.authorMartin, B. J.en_US
dc.contributor.authorPittenger, M. F.en_US
dc.contributor.authorHare, J. M.en_US
dc.contributor.authorBulte, J. W. M.en_US
dc.date.accessioned2016-02-08T10:30:03Z
dc.date.available2016-02-08T10:30:03Z
dc.date.issued2003en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.description.abstractBackground - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:30:03Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2003en
dc.identifier.doi10.1161/01.CIR.0000070931.62772.4Een_US
dc.identifier.issn0009-7322
dc.identifier.urihttp://hdl.handle.net/11693/24482
dc.language.isoEnglishen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.isversionofhttp://dx.doi.org/10.1161/01.CIR.0000070931.62772.4Een_US
dc.source.titleCirculationen_US
dc.subjectCellsen_US
dc.subjectContrast mediaen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectMyocardial infarctionen_US
dc.subjectAnimal cellen_US
dc.subjectAnimal experimenten_US
dc.subjectAnimal modelen_US
dc.subjectContrast enhancementen_US
dc.subjectDeviceen_US
dc.subjectFeasibility studyen_US
dc.subjectFluoroscopyen_US
dc.subjectHeart infarctionen_US
dc.subjectMesenchymeen_US
dc.subjectNonhumanen_US
dc.subjectNuclear magnetic resonance imagingen_US
dc.subjectPriority journalen_US
dc.subjectStem cellen_US
dc.subjectSwineen_US
dc.subjectTechniqueen_US
dc.subjectAnimalsen_US
dc.subjectInjectionsen_US
dc.subjectIronen_US
dc.subjectMyocardiumen_US
dc.subjectStem Cell Transplantationen_US
dc.subjectStem Cellsen_US
dc.subjectSwineen_US
dc.titleIn vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarctionen_US
dc.typeArticleen_US

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