In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
Date
2003
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
BUIR Usage Stats
2
views
views
15
downloads
downloads
Citation Stats
Attention Stats
Series
Abstract
Background - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
Source Title
Circulation
Publisher
Lippincott Williams & Wilkins
Course
Other identifiers
Book Title
Keywords
Cells, Contrast media, Magnetic resonance imaging, Myocardial infarction, Animal cell, Animal experiment, Animal model, Contrast enhancement, Device, Feasibility study, Fluoroscopy, Heart infarction, Mesenchyme, Nonhuman, Nuclear magnetic resonance imaging, Priority journal, Stem cell, Swine, Technique, Animals, Injections, Iron, Myocardium, Stem Cell Transplantation, Stem Cells, Swine
Degree Discipline
Degree Level
Degree Name
Citation
Permalink
Published Version (Please cite this version)
Language
English