In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction

Date
2003
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Circulation
Print ISSN
0009-7322
Electronic ISSN
Publisher
Lippincott Williams & Wilkins
Volume
107
Issue
18
Pages
2290 - 2293
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Series
Abstract

Background - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.

Course
Other identifiers
Book Title
Keywords
Cells, Contrast media, Magnetic resonance imaging, Myocardial infarction, Animal cell, Animal experiment, Animal model, Contrast enhancement, Device, Feasibility study, Fluoroscopy, Heart infarction, Mesenchyme, Nonhuman, Nuclear magnetic resonance imaging, Priority journal, Stem cell, Swine, Technique, Animals, Injections, Iron, Myocardium, Stem Cell Transplantation, Stem Cells, Swine
Citation
Published Version (Please cite this version)