In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
Date
2003
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Circulation
Print ISSN
0009-7322
Electronic ISSN
Publisher
Lippincott Williams & Wilkins
Volume
107
Issue
18
Pages
2290 - 2293
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Series
Abstract
Background - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
Course
Other identifiers
Book Title
Keywords
Cells , Contrast media , Magnetic resonance imaging , Myocardial infarction , Animal cell , Animal experiment , Animal model , Contrast enhancement , Device , Feasibility study , Fluoroscopy , Heart infarction , Mesenchyme , Nonhuman , Nuclear magnetic resonance imaging , Priority journal , Stem cell , Swine , Technique , Animals , Injections , Iron , Myocardium , Stem Cell Transplantation , Stem Cells , Swine