Designing BODIPY-based probes for fluorescence imaging of b-amyloid plaques

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Date

2014

Authors

Sozmen, F.
Kolemen, S.
Kumada, H. O.
Ono, M.
Saji, H.
Akkaya, E. U.

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Abstract

Styryl-congutated BODIPY dyes which are structurally similar to known Ab peptide binding dyes, were designed and synthesized. The binding is accompanied by a large increase in the emission intensity in all cases, suggesting a high potential for use in the fluorescence imaging of Ab plaques.

Source Title

RSC Advances

Publisher

Royal Society of Chemistry

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Keywords

Photodynamic Therapy, Protein Aggregation, Dyes, Neurodegeneration, Hotosensitizers, Therapeutics, Derivatives

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Permalink

http://hdl.handle.net/11693/12595

Published Version (Please cite this version)

http://dx.doi.org/10.1039/c4ra07754g

Collections

Scholarly Publications - Chemistry
Scholarly Publications - UNAM

Language

English

Type

Article