Fabrication of nanowalled catalytically self-threaded supramolecular polyrotaxane microcapsules using droplet microfluidics

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buir.contributor.authorAlizadeh-Haghighi, Elnaz
buir.contributor.authorKhaligh, Aisan
buir.contributor.authorKalantarifard, Ali
buir.contributor.authorElbuken, Caglar
buir.contributor.authorTuncel, Dönüs
buir.contributor.orcidKhaligh, Aisan|0000-0002-5419-1020
buir.contributor.orcidKalantarifard, Ali|0000-0002-7931-6264
buir.contributor.orcidElbuken, Caglar|0000-0001-8359-6871
buir.contributor.orcidTuncel, Dönüs|0000-0001-7762-9200
dc.citation.epage4688en_US
dc.citation.issueNumber7en_US
dc.citation.spage4681en_US
dc.citation.volumeNumber4en_US
dc.contributor.authorAlizadeh-Haghighi, Elnaz
dc.contributor.authorKhaligh, Aisan
dc.contributor.authorKalantarifard, Ali
dc.contributor.authorElbuken, Caglar
dc.contributor.authorTuncel, Dönüs
dc.date.accessioned2023-02-14T08:08:27Z
dc.date.available2023-02-14T08:08:27Z
dc.date.issued2022-04-11
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)
dc.description.abstractMicrometer-scale monodisperse droplets are produced to generate nanowalled supramolecular microcapsules using microfluidics for high reproducibility and high-throughput manipulation, efficient material consumption, and control over hierarchical structure, shape, and size. In this study, an optimized microfluidic droplet generation technique and a unique liquid-liquid interfacial polymerization method were applied to fabricate the monodisperse polyrotaxane-based supramolecular microcapsules in a fast and simple way. To minimize the uncertainty due to droplet volume variation, the inlet pressures were supplied from the same source while lowering the interfacial tension and the main channel hydrodynamic resistance, which are critical for high monodispersity. The target polyrotaxane network (PN) was simply formed at the interface of the water and oil phases in ultra-monodisperse microdroplets via the cucurbit[6]uril (CB6)-catalyzed azide-alkyne cycloaddition (CB6-AAC) reaction between azido- and alkyne-functionalized tetraphenylporphyrin monomers (TPP-4AZ and TPP-4AL). The thickness of the interfacially assembled PN microcapsules was 20 nm as analyzed by cross-sectional TEM and TEM-EDX techniques. The resultant water-in-oil PN microcapsules were highly monodisperse in size and able to retain target molecules. Here, rhodamine 6G (Rh6G)-loaded PN microcapsules were fabricated, and the release rate of the Rh6G cargo was investigated over time for controlled drug release applications.en_US
dc.description.provenanceSubmitted by Mücahit Yazıcı (yazicimucahit300@gmail.com) on 2023-02-14T08:08:27Z No. of bitstreams: 1 Fabrication_of_nanowalled_catalytically_self-threaded_supramolecular_polyrotaxane_microcapsules_using_droplet_microfluidics.pdf: 7529201 bytes, checksum: ac33e743c9ae9e7f6312c56b31cbc890 (MD5)en
dc.description.provenanceMade available in DSpace on 2023-02-14T08:08:27Z (GMT). No. of bitstreams: 1 Fabrication_of_nanowalled_catalytically_self-threaded_supramolecular_polyrotaxane_microcapsules_using_droplet_microfluidics.pdf: 7529201 bytes, checksum: ac33e743c9ae9e7f6312c56b31cbc890 (MD5) Previous issue date: 2022-04-11en
dc.identifier.doi10.1021/acsapm.2c00195en_US
dc.identifier.eissn2637-6105
dc.identifier.issn26376105
dc.identifier.urihttp://hdl.handle.net/11693/111235
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://dx.doi.org/10.1021/acsapm.2c00195en_US
dc.source.titleACS Applied Polymer Materialsen_US
dc.subjectMicrofluidicsen_US
dc.subjectNanowalled microcapsulesen_US
dc.subjectMonodispersityen_US
dc.subjectSupramoleculesen_US
dc.subject2D polyrotaxane networken_US
dc.subjectInterfacial polymerizationen_US
dc.subjectDrug releaseen_US
dc.titleFabrication of nanowalled catalytically self-threaded supramolecular polyrotaxane microcapsules using droplet microfluidicsen_US
dc.typeArticleen_US

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