Towards microwave imaging of cells

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buir.contributor.authorKelleci, Mehmet
buir.contributor.authorAydoğmuş, Hande
buir.contributor.authorAslanbaş, Levent
buir.contributor.authorErbil, Selçuk Oğuz
buir.contributor.authorHanay, M. Selim
dc.citation.epage472en_US
dc.citation.issueNumber3en_US
dc.citation.spage463en_US
dc.citation.volumeNumber18en_US
dc.contributor.authorKelleci, Mehmeten_US
dc.contributor.authorAydoğmuş, Handeen_US
dc.contributor.authorAslanbaş, Leventen_US
dc.contributor.authorErbil, Selçuk Oğuzen_US
dc.contributor.authorHanay, M. Selimen_US
dc.date.accessioned2019-02-21T16:02:43Zen_US
dc.date.available2019-02-21T16:02:43Zen_US
dc.date.issued2018en_US
dc.departmentDepartment of Mechanical Engineeringen_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractIntegrated detection techniques that can characterize the morphological properties of cells are needed for the widespread use of lab-on-a-chip technology. Herein, we establish a theoretical and experimental framework to use resonant microwave sensors in their higher order modes so that the morphological properties of analytes inside a microfluidic channel can be obtained electronically. We built a phase-locked loop system that can track the first two modes of a microstrip line resonator to detect the size and location of microdroplets and cells passing through embedded microfluidic channels. The attained resolution, expressed in terms of Allan deviation at the response time, is as small as 2 × 10-8 for both modes. Additionally, simulations were performed to show that sensing with higher order modes can yield the geometrical volume, effective permittivity, two-dimensional extent, and the orientation of analytes. The framework presented here makes it possible to develop a novel type of microscope that operates at the microwave band, i.e., a radar for cells.en_US
dc.description.provenanceMade available in DSpace on 2019-02-21T16:02:43Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en
dc.identifier.doi10.1039/c7lc01251aen_US
dc.identifier.doi10.1039/c7lc01251aen_US
dc.identifier.eissn1473-0189en_US
dc.identifier.issn1473-0197en_US
dc.identifier.urihttp://hdl.handle.net/11693/50035en_US
dc.language.isoEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.1039/c7lc01251aen_US
dc.source.titleLab on a Chipen_US
dc.titleTowards microwave imaging of cellsen_US
dc.typeArticleen_US

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