Collagen peptide presenting nanofibrous scaffold for intervertebral disc regeneration

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buir.contributor.authorUysal, Özge
buir.contributor.authorArslan, Elif
buir.contributor.authorGülseren, Gülcihan
buir.contributor.authorTekinay, Ayşe B.
dc.citation.epage1695en_US
dc.citation.issueNumber4en_US
dc.citation.spage1686en_US
dc.citation.volumeNumber2en_US
dc.contributor.authorUysal, Özgeen_US
dc.contributor.authorArslan, Elifen_US
dc.contributor.authorGülseren, Gülcihanen_US
dc.contributor.authorKılınç, M. C.en_US
dc.contributor.authorDoğan, İ.en_US
dc.contributor.authorÖzalp, H.en_US
dc.contributor.authorÇağlar, Y. Ş.en_US
dc.contributor.authorGüler, M. O.en_US
dc.contributor.authorTekinay, Ayşe B.en_US
dc.date.accessioned2020-02-13T06:40:31Z
dc.date.available2020-02-13T06:40:31Z
dc.date.issued2019
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.description.abstractLower back pain (LBP) is a prevalent spinal symptom at the lumbar region of the spine, which severely effects quality of life and constitutes the number one cause of occupational disability. Degeneration of the intervertebral disc (IVD) is one of the well-known causes contributing to the LBP. Therapeutic biomaterials inducing IVD regeneration are promising candidates for IVD degeneration treatments. Here, we demonstrate a collagen peptide presenting nanofiber scaffold to mimic the structure and function of the natural extracellular matrix of the tissue for IVD regeneration. The collagen peptide presenting nanofiber was designed by using a Pro-Hyp-Gly (POG) peptide sequence on a self-assembling peptide amphiphile molecule, which assembled into nanofibers forming scaffolds. Injection of collagen peptide presenting peptide nanofiber scaffold into the degenerated rabbit IVDs induced more glycosaminoglycan and collagen deposition compared to controls. Functional recovery of the tissue was evaluated by degeneration index score, where the bioactive scaffold was shown to provide functional recovery of the IVD degeneration. These results showed that the collagen peptide presenting nanofiber scaffold can prevent the progression of IVD degeneration and provide further functional recovery of the tissue.en_US
dc.identifier.doi10.1021/acsabm.9b00062en_US
dc.identifier.issn2576-6422
dc.identifier.urihttp://hdl.handle.net/11693/53324
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://dx.doi.org/10.1021/acsabm.9b00062en_US
dc.source.titleACS Applied Bio Materialsen_US
dc.subjectCollagenen_US
dc.subjectIntervertebral disc degenerationen_US
dc.subjectNeedle puncture modelen_US
dc.subjectPeptide nanofiberen_US
dc.subjectRegenerationen_US
dc.titleCollagen peptide presenting nanofibrous scaffold for intervertebral disc regenerationen_US
dc.typeArticleen_US

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Institute of Materials Science and Nanotechnology (UNAM)
Aysel Sabuncu Brain Research Center (BAM)
Nanotechnology Research Center (NANOTAM)