Dual functionality of conjugated polymer nanoparticles as an anticancer drug carrier and a fluorescent probe for cell imaging

Date
2014
Authors
Gezici, Ö.
Durmaz, I.
Güven, E. B.
Ünal, Ö.
Özgün, A.
Cetin Atalay, R.
Tuncel, D.
Advisor
Instructor
Source Title
RSC Advances
Print ISSN
2046-2069
Electronic ISSN
Publisher
Royal Society of Chemistry
Volume
4
Issue
3
Pages
1302 - 1309
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

Multifunctional nanoparticles based on a green emitting, hydrophobic conjugated polymer, poly[(9,9-bis{propeny}fluorenyl-2,7-diyl)-co-(1,4-benzo-{2,1,3}-thiodiazole)] (PPFBT), that acts both as a fluorescent reporter and a matrix to accommodate an anti-cancer compound, camptothecin (CPT), were prepared, characterized and their potential as a fluorescent probe for cell imaging and as a drug delivery vehicle were evaluated via in vitro cell assays. The cell viability of human hepatocellular carcinoma cell line (Huh7) was investigated in the absence and presence of CPT with sulforhodamine B (SRB) and real-time cell electronic sensing (RT-CES) cytotoxicity assays.

Course
Other identifiers
Book Title
Keywords
Camptothecin (CPT), Cytotoxicity assays, Drug delivery vehicles, Fluorescent reporter, Hepatocellular carcinoma cell, Multi-functional nanoparticles, Polymer nanoparticles, Real-time cell electronic sensing, Drug delivery, Cell culture
Citation
Published Version (Please cite this version)