Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases

Date

2009

Authors

Chabchoub, G.
Uz, E.
Maalej, A.
Mustafa, C. A.
Rebai, A.
Mnif, M.
Bahloul, Z.
Farid, N. R.
Ozcelik, T.
Ayadi, H.

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Abstract

Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases.

Source Title

Arthritis Research and Therapy

Publisher

BioMed Central

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Published Version (Please cite this version)

Language

English