Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases
Date
2009
Authors
Chabchoub, G.
Uz, E.
Maalej, A.
Mustafa, C. A.
Rebai, A.
Mnif, M.
Bahloul, Z.
Farid, N. R.
Ozcelik, T.
Ayadi, H.
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Arthritis Research and Therapy
Print ISSN
1478-6362
Electronic ISSN
Publisher
BioMed Central
Volume
11
Issue
4
Pages
1 - 8
Language
English
Type
Journal Title
Journal ISSN
Volume Title
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4
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4
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Abstract
Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases.
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Book Title
Keywords
Androgen receptor, Cyclic citrullinated peptide antibody, Hydroxychloroquine, Methotrexate, Penicillamine, Rheumatoid factor, Autoantibody, Allele, Autoimmune thyroiditis, Chromosome analysis, Controlled study, Female, Genetic association, Genetic predisposition, Human, Immunosuppressive treatment, Major clinical study, Phenotype, Polymerase chain reaction, X chromosome inactivation, Autoimmune disease, Blood, Enzyme linked immunosorbent assay, Genetics, Middle aged, Rheumatoid arthritis, Thyroid disease, X chromosome, Adult, Arthritis, Rheumatoid, Autoantibodies, Autoimmune Diseases, Chromosomes, Human, X, Enzyme-Linked Immunosorbent Assay, Fluorescent Antibody Technique, Genetic Predisposition to Disease, Humans, Polymerase Chain Reaction, Thyroid Diseases, Tunisia