Covalently functionalized MSNs as potential photosensitizing agents for PDT

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buir.advisorAkkaya, Engin U.
dc.contributor.authorTürkşanlı Kaplan, Merve
dc.date.accessioned2016-01-08T18:13:40Z
dc.date.available2016-01-08T18:13:40Z
dc.date.issued2011
dc.descriptionAnkara : The Graduate Program of Materials Science and Nanotechnology and the Institute of Engineering and Sciences of Bilkent University, 2011.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2011.en_US
dc.descriptionIncludes bibliographical references leaves 42-45.en_US
dc.description.abstractPhotodynamic therapy (PDT) is a novel approach for the treatment of some cancers and other non-malignant diseases. PDT aims to kill cancer tissue by the generation of singlet oxygen as a result of excitation of the photosensitizer (PS) by illuminating with a light source at a certain wavelength. Mesoporous silica nanoparticles are promising in PDT issue due to their chemical inertness, biocompatibility, lowtoxicity, hydrophility and ease of surface modification. We have synthesized and characterized novel boradiazaindacene (BODIPY)-based PS that is covalently attached to the pore of mesoporous silica nanoparticles (MSNs). We have observed that near infrared absorbing photosensitizer attached MSNs successfully generate cytotoxic singlet oxygen.en_US
dc.description.provenanceMade available in DSpace on 2016-01-08T18:13:40Z (GMT). No. of bitstreams: 1 0004068.pdf: 2920808 bytes, checksum: ce1069c55207646720166067828c1f2e (MD5)en
dc.description.statementofresponsibilityKaplan, Merve Türkşanlıen_US
dc.format.extentxii, 60 leaves, illustrationsen_US
dc.identifier.itemidB125581
dc.identifier.urihttp://hdl.handle.net/11693/15111
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoradiazaindaceneen_US
dc.subjectDrug carrier systemen_US
dc.subjectMesoporous silica nanoparticlesen_US
dc.subjectPhotosensitizeren_US
dc.subjectPhotodynamic therapyen_US
dc.subject.lccTA418.9.P6 K37 2011en_US
dc.subject.lcshPorous materials.en_US
dc.subject.lcshNanostructured materials.en_US
dc.subject.lcshPhotochemotherapy.en_US
dc.subject.lcshNanoparticles.en_US
dc.titleCovalently functionalized MSNs as potential photosensitizing agents for PDTen_US
dc.typeThesisen_US
thesis.degree.disciplineMaterials Science and Nanotechnology
thesis.degree.grantorBilkent University
thesis.degree.levelMaster's
thesis.degree.nameMS (Master of Science)

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