Covalently functionalized MSNs as potential photosensitizing agents for PDT

Date

2011

Editor(s)

Advisor

Akkaya, Engin U.

Supervisor

Co-Advisor

Co-Supervisor

Instructor

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Abstract

Photodynamic therapy (PDT) is a novel approach for the treatment of some cancers and other non-malignant diseases. PDT aims to kill cancer tissue by the generation of singlet oxygen as a result of excitation of the photosensitizer (PS) by illuminating with a light source at a certain wavelength. Mesoporous silica nanoparticles are promising in PDT issue due to their chemical inertness, biocompatibility, lowtoxicity, hydrophility and ease of surface modification. We have synthesized and characterized novel boradiazaindacene (BODIPY)-based PS that is covalently attached to the pore of mesoporous silica nanoparticles (MSNs). We have observed that near infrared absorbing photosensitizer attached MSNs successfully generate cytotoxic singlet oxygen.

Source Title

Publisher

Course

Other identifiers

Book Title

Degree Discipline

Materials Science and Nanotechnology

Degree Level

Master's

Degree Name

MS (Master of Science)

Citation

Published Version (Please cite this version)

Language

English

Type