Chiral ceramic nanoparticles and peptide catalysis

Simple item page
buir.contributor.authorDemir, Hilmi Volkan
buir.contributor.orcidDemir, Hilmi Volkan|0000-0003-1793-112X
dc.citation.epage13712en_US
dc.citation.issueNumber39en_US
dc.citation.spage13701en_US
dc.citation.volumeNumber139en_US
dc.contributor.authorJiang S.en_US
dc.contributor.authorChekini, M.en_US
dc.contributor.authorQu, Z.-B.en_US
dc.contributor.authorWang Y.en_US
dc.contributor.authorYeltik A.en_US
dc.contributor.authorLiu, Y.en_US
dc.contributor.authorKotlyar, A.en_US
dc.contributor.authorZhang, T.en_US
dc.contributor.authorLi, B.en_US
dc.contributor.authorDemir, Hilmi Volkanen_US
dc.contributor.authorKotov, N. A.en_US
dc.date.accessioned2018-04-12T11:08:16Z
dc.date.available2018-04-12T11:08:16Z
dc.date.issued2017en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Physicsen_US
dc.description.abstractThe chirality of nanoparticles (NPs) and their assemblies has been investigated predominantly for noble metals and II-VI semiconductors. However, ceramic NPs represent the majority of nanoscale materials in nature. The robustness and other innate properties of ceramics offer technological opportunities in catalysis, biomedical sciences, and optics. Here we report the preparation of chiral ceramic NPs, as represented by tungsten oxide hydrate, WO3-x·H2O, dispersed in ethanol. The chirality of the metal oxide core, with an average size of ca. 1.6 nm, is imparted by proline (Pro) and aspartic acid (Asp) ligands via bio-to-nano chirality transfer. The amino acids are attached to the NP surface through C-O-W linkages formed from dissociated carboxyl groups and through amino groups weakly coordinated to the NP surface. Surprisingly, the dominant circular dichroism bands for NPs coated by Pro and Asp are different despite the similarity in the geometry of the NPs; they are positioned at 400-700 nm and 500-1100 nm for Pro- and Asp-modified NPs, respectively. The differences in the spectral positions of the main chiroptical band for the two types of NPs are associated with the molecular binding of the two amino acids to the NP surface; Asp has one additional C-O-W linkage compared to Pro, resulting in stronger distortion of the inorganic crystal lattice and greater intensity of CD bands associated with the chirality of the inorganic core. The chirality of WO3-x·H2O atomic structure is confirmed by atomistic molecular dynamics simulations. The proximity of the amino acids to the mineral surface is associated with the catalytic abilities of WO3-x·H2O NPs. We found that NPs facilitate formation of peptide bonds, leading to Asp-Asp and Asp-Pro dipeptides. The chiroptical activity, chemical reactivity, and biocompatibility of tungsten oxide create a unique combination of properties relevant to chiral optics, chemical technologies, and biomedicine.en_US
dc.identifier.doi10.1021/jacs.7b01445en_US
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/11693/37273
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/jacs.7b01445en_US
dc.source.titleJournal of the American Chemical Societyen_US
dc.subjectAmino acidsen_US
dc.subjectBiocompatibilityen_US
dc.subjectCatalysisen_US
dc.subjectCeramic materialsen_US
dc.subjectChiralityen_US
dc.subjectCrystal atomic structureen_US
dc.subjectDichroismen_US
dc.subjectMetal nanoparticlesen_US
dc.subjectMetalsen_US
dc.subjectMolecular dynamicsen_US
dc.subjectNanoparticlesen_US
dc.subjectOxidesen_US
dc.subjectPeptidesen_US
dc.subjectPolymethyl methacrylatesen_US
dc.subjectTungstenen_US
dc.subjectTungsten compoundsen_US
dc.subjectAtomistic molecular dynamics simulationsen_US
dc.subjectBiomedical scienceen_US
dc.subjectCeramic nanoparticlesen_US
dc.subjectChemical technologiesen_US
dc.subjectChirality transferen_US
dc.subjectNano-scale materialsen_US
dc.subjectNanoparticle (NPs)en_US
dc.subjectTechnological opportunityen_US
dc.subjectStereochemistryen_US
dc.titleChiral ceramic nanoparticles and peptide catalysisen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Chiral Ceramic Nanoparticles and Peptide Catalysis.pdf
Size:
7.06 MB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download

Collections

Department of Electrical and Electronics Engineering
Department of Physics
Institute of Materials Science and Nanotechnology (UNAM)