Fast-dissolving carvacrol/cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activity

buir.contributor.authorUyar, Tamer
buir.contributor.authorDurgun, Engin
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage15849en_US
dc.citation.issueNumber23en_US
dc.citation.spage15837en_US
dc.citation.volumeNumber53en_US
dc.contributor.authorYildiz, Z. İ.en_US
dc.contributor.authorCelebioglu A.en_US
dc.contributor.authorKilic, M. E.en_US
dc.contributor.authorDurgun, Enginen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2019-02-21T16:10:22Zen_US
dc.date.available2019-02-21T16:10:22Zen_US
dc.date.issued2018en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractCarvacrol is a known antioxidant molecule and commonly used in food and cosmetics as a flavor and fragrance agent; however, carvacrol has major issues such as high volatility, low water solubility, and stability. In this study, carvacrol/cyclodextrin inclusion complex fibers (carvacrol/CD-IC fibers) were produced via electrospinning in order to enhance thermal stability, water solubility and shelf-life of carvacrol having antioxidant activity. The phase solubility and computational modeling studies showed that carvacrol can form inclusion complexes with two types of modified CDs, hydroxypropyl-β-cyclodextrin (HPβCD) and hydroxypropyl-γ-cyclodextrin (HPγCD). The carvacrol/cyclodextrin inclusion complex electrospun fibers (carvacrol/HPβCD-IC fibers and carvacrol/HPγCD-IC fibers) were obtained as free-standing fibrous webs. Although pure carvacrol is highly volatile, the electrospun carvacrol/CD-IC fibers were quite effective to preserve high amount of carvacrol due to the inclusion complexation. In addition, carvacrol/CD-IC fibers have shown higher temperature stability for carvacrol. Moreover, carvacrol/CD-IC fibers showed more effective antioxidant activity as compared to pure carvacrol. The carvacrol/CD-IC fibrous webs have shown fast-dissolving character in water due to the enhanced water solubility of carvacrol/CD-IC and their ultrafine fiber structure. In short, encapsulation of carvacrol in electrospun CD-IC fibrous webs has shown potentials for food and oral care applications due to free-standing and fast-dissolving character along with high water solubility, high temperature stability and enhanced antioxidant by carvacrol/cyclodextrin inclusion complexation.en_US
dc.description.provenanceMade available in DSpace on 2019-02-21T16:10:22Z (GMT). No. of bitstreams: 1 Bilkent-research-paper.pdf: 222869 bytes, checksum: 842af2b9bd649e7f548593affdbafbb3 (MD5) Previous issue date: 2018en_US
dc.description.sponsorshipDr. Uyar acknowledges The Scientific and Technological Research Council of Turkey (TUBITAK), Turkey (Project #213M185) for funding this research. Z. I. Yildiz thanks to TUBITAK-BIDEB for the PhD scholarship. Dr. Durgun acknowledges the support from the Turkish Academy of Sciences—Outstanding Young Scientists Award Program (TUBA-GEBIP)— Turkey.en_US
dc.identifier.doi10.1007/s10853-018-2750-1en_US
dc.identifier.eissn1573-4803en_US
dc.identifier.issn0022-2461en_US
dc.identifier.urihttp://hdl.handle.net/11693/50502en_US
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.isversionofhttps://doi.org/10.1007/s10853-018-2750-1en_US
dc.relation.projectTürkiye Bilimler Akademisi, TÜBA - 213M185en_US
dc.source.titleJournal of Materials Scienceen_US
dc.titleFast-dissolving carvacrol/cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activityen_US
dc.typeArticleen_US

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