Lipid melting transitions involve structural redistribution of interfacial water

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buir.contributor.authorOkur, Halil İbrahim
buir.contributor.orcidOkur, Halil İbrahim|0000-0002-2492-1168
dc.citation.epage12465en_US
dc.citation.issueNumber45en_US
dc.citation.spage12457en_US
dc.citation.volumeNumber125en_US
dc.contributor.authorSchönfeldová, T.
dc.contributor.authorPiller, P.
dc.contributor.authorKovacik, F.
dc.contributor.authorPabst, G.
dc.contributor.authorOkur, Halil İbrahim
dc.contributor.authorRoke, S.
dc.date.accessioned2022-02-22T07:52:14Z
dc.date.available2022-02-22T07:52:14Z
dc.date.issued2021-11-03
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractMorphological and gel-to-liquid phase transitions of lipid membranes are generally considered to primarily depend on the structural motifs in the hydrophobic core of the bilayer. Structural changes in the aqueous headgroup phase are typically not considered, primarily because they are difficult to quantify. Here, we investigate structural changes of the hydration shells around large unilamellar vesicles (LUVs) in aqueous solution, using differential scanning calorimetry (DSC), and temperature-dependent ζ-potential and high-throughput angle-resolved second harmonic scattering measurements (AR-SHS). Varying the lipid composition from 1,2-dimyristoyl-sn-glycero-3-phosphocholine(DMPC) to 1,2-dimyristoyl-sn-glycero-3-phosphate (DMPA), to 1,2-dimyristoyl-sn-glycero-3-phospho-l-serine (DMPS), we observe surprisingly distinct behavior for the different systems that depend on the chemical composition of the hydrated headgroups. These differences involve changes in hydration following temperature-induced counterion redistribution, or changes in hydration following headgroup reorientation and Stern layer compression.en_US
dc.description.provenanceSubmitted by Dilan Ayverdi (dilan.ayverdi@bilkent.edu.tr) on 2022-02-22T07:52:14Z No. of bitstreams: 1 Lipid_melting_transitions_involve_structural_redistribution_of_interfacial_water.pdf: 1837360 bytes, checksum: 75f6ed79a930516529c1c96d11909a0d (MD5)en
dc.description.provenanceMade available in DSpace on 2022-02-22T07:52:14Z (GMT). No. of bitstreams: 1 Lipid_melting_transitions_involve_structural_redistribution_of_interfacial_water.pdf: 1837360 bytes, checksum: 75f6ed79a930516529c1c96d11909a0d (MD5) Previous issue date: 2021-11-03en
dc.identifier.doi10.1021/acs.jpcb.1c06868en_US
dc.identifier.eissn1520-5207
dc.identifier.issn1520-6106
dc.identifier.urihttp://hdl.handle.net/11693/77547
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://doi.org/10.1021/acs.jpcb.1c06868en_US
dc.source.titleThe Journal of Physical Chemistry Part Ben_US
dc.subjectLipidsen_US
dc.subjectScatteringen_US
dc.subjectHydrationen_US
dc.subjectPolarizationen_US
dc.subjectPhase transitionsen_US
dc.titleLipid melting transitions involve structural redistribution of interfacial wateren_US
dc.typeArticleen_US

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