Engineering mammalian cell for cancer

Abstract

The accuracy of products produced by mammalian cells can be explained by the fact that continuously stored environmental information leads to high-precision production capacity. Therefore, usage of mammalian cells in cancer might lead to progression of safe and efficient therapies. Synthetic biology has emerged as a transformative force in biomedical innovation, which aims to reprogram cells for precise diagnostics and therapeutics. Recent advances highlight the development of modular synthetic receptors, enabling customizable disease recognition and engineered mammalian cells exhibiting remarkable sensitivity and selectivity. Simultaneously, advances in mammalian synthetic biology facilitate the deliberate engineering of protein secretion, glycosylation, cellular metabolism, and cellular communication, unlocking new therapeutic possibilities that even lead to the construction of artificial tissues for innovative cancer therapies. This chapter focuses on the current techniques of mammalian cell engineering for cancer therapeutics including their drawbacks and future. © 2025 Walter de Gruyter GmbH, Berlin/Boston.