Peptide functionalized superparamagnetic iron oxide nanoparticles as MRI contrast agents

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buir.contributor.authorAtalar, Ergin
buir.contributor.authorGüler, Mustafa O.
dc.citation.epage15162en_US
dc.citation.issueNumber39en_US
dc.citation.spage15157en_US
dc.citation.volumeNumber21en_US
dc.contributor.authorSulek, S.en_US
dc.contributor.authorMammadov, B.en_US
dc.contributor.authorMahcicek, D. I.en_US
dc.contributor.authorSozeri, H.en_US
dc.contributor.authorAtalar, Erginen_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.date.accessioned2016-02-08T09:50:37Z
dc.date.available2016-02-08T09:50:37Z
dc.date.issued2011en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.description.abstractMagnetic resonance imaging (MRI) attracts great attention in cellular and molecular imaging due to its non-invasive and multidimensional tomographic capabilities. Development of new contrast agents is necessary to enhance the MRI signal in tissues of interest. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents for signal enhancement as they have revealed extraordinary magnetic properties at the nanometre size and their toxicity level is very low compared to other commercial contrast agents. In this study, we developed a new method to functionalize the surface of SPIONs. Peptide amphiphile molecules are used to coat SPIONs non-covalently to provide water solubility and to enhance biocompatibility. Superparamagnetic properties of the peptide-SPION complexes and their ability as contrast agents are demonstrated. In vitro cell culture experiments reveal that the peptide-SPION complexes are biocompatible and are localized around the cells due to their peptide coating.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:50:37Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2011en
dc.identifier.doi10.1039/c1jm11387aen_US
dc.identifier.issn0959-9428
dc.identifier.urihttp://hdl.handle.net/11693/21746
dc.language.isoEnglishen_US
dc.publisherThe Royal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c1jm11387aen_US
dc.source.titleJournal of Materials Chemistryen_US
dc.subjectContrast agenten_US
dc.subjectFunctionalizeden_US
dc.subjectIn-vitroen_US
dc.subjectMolecular imagingen_US
dc.subjectMRI contrast agentsen_US
dc.subjectNanometresen_US
dc.subjectNon-invasiveen_US
dc.subjectPeptide amphiphilesen_US
dc.subjectPeptide coatingen_US
dc.subjectSignal enhancementen_US
dc.subjectSuperparamagnetic iron oxide nanoparticlesen_US
dc.subjectSuperparamagnetic propertyen_US
dc.subjectTomographicen_US
dc.subjectWater solubilitiesen_US
dc.subjectBiocompatibilityen_US
dc.subjectCell cultureen_US
dc.subjectMagnetic propertiesen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectNanomagneticsen_US
dc.subjectNanoparticlesen_US
dc.subjectPeptidesen_US
dc.subjectSignal systemsen_US
dc.subjectSuperparamagnetismen_US
dc.subjectTissueen_US
dc.subjectIron oxidesen_US
dc.titlePeptide functionalized superparamagnetic iron oxide nanoparticles as MRI contrast agentsen_US
dc.typeArticleen_US

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