Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers

Date
2014
Advisor
Instructor
Source Title
Colloids and Surfaces B: Biointerfaces
Print ISSN
0927-7765
Electronic ISSN
Publisher
Elsevier
Volume
120
Issue
Pages
125 - 131
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.

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Keywords
Allyl isothiocyanate, Antibacterial activity, Electrospinning, Nanofibers, Release, β-Cyclodextrin, Bacteria, Cyclodextrins, Electrospinning, Escherichia coli, Allyl isothiocyanate, Anti-bacterial activity, Cyclodextrin complexes, Electrospinning process, Electrospun nanofibers, Inclusion complexation, Poly (vinyl alcohol) (PVA), Release, Nanofibers, allyl isothiocyanate, beta cyclodextrin, nanofiber, polyvinyl alcohol, allyl isothiocyanate, antiinfective agent, beta cyclodextrin, beta cyclodextrin derivative, isothiocyanic acid derivative, nanofiber, solution and solubility, article, bactericidal activity, bacterium colony, complex formation, concentration (parameters), controlled study, crystal structure, electrospinning, Escherichia coli, evaporation, mass fragmentography, nanoencapsulation, nonhuman, priority journal, proton nuclear magnetic resonance, scanning electron microscopy, Staphylococcus aureus, tensile strength, bacterial count, chemistry, drug effects, drug release, growth, development and aging, microbial sensitivity test, nanotechnology, procedures, solution and solubility, ultrastructure, X ray diffraction, Anti-Bacterial Agents, beta-Cyclodextrins, Colony Count, Microbial, Drug Liberation, Escherichia coli, Isothiocyanates, Microbial Sensitivity Tests, Nanofibers, Nanotechnology, Proton Magnetic Resonance Spectroscopy, Solutions, Staphylococcus aureus, X-Ray Diffraction
Citation
Published Version (Please cite this version)