Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers

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Release and antibacterial activity of allyl isothiocyanateβ-cyclodextrin complex encapsulated in electrospun nanofibers.pdf (2.01 MB)

Date

2014

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Source Title

Colloids and Surfaces B: Biointerfaces

Print ISSN

0927-7765

Electronic ISSN

Publisher

Elsevier

Volume

120

Issue

Pages

125 - 131

Language

English

Type

Article

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Abstract

Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.

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Keywords

Allyl isothiocyanate , Antibacterial activity , Electrospinning , Nanofibers , Release , β-Cyclodextrin , Bacteria , Cyclodextrins , Electrospinning , Escherichia coli , Allyl isothiocyanate , Anti-bacterial activity , Cyclodextrin complexes , Electrospinning process , Electrospun nanofibers , Inclusion complexation , Poly (vinyl alcohol) (PVA) , Release , Nanofibers , allyl isothiocyanate , beta cyclodextrin , nanofiber , polyvinyl alcohol , allyl isothiocyanate , antiinfective agent , beta cyclodextrin , beta cyclodextrin derivative , isothiocyanic acid derivative , nanofiber , solution and solubility , article , bactericidal activity , bacterium colony , complex formation , concentration (parameters) , controlled study , crystal structure , electrospinning , Escherichia coli , evaporation , mass fragmentography , nanoencapsulation , nonhuman , priority journal , proton nuclear magnetic resonance , scanning electron microscopy , Staphylococcus aureus , tensile strength , bacterial count , chemistry , drug effects , drug release , growth, development and aging , microbial sensitivity test , nanotechnology , procedures , solution and solubility , ultrastructure , X ray diffraction , Anti-Bacterial Agents , beta-Cyclodextrins , Colony Count, Microbial , Drug Liberation , Escherichia coli , Isothiocyanates , Microbial Sensitivity Tests , Nanofibers , Nanotechnology , Proton Magnetic Resonance Spectroscopy , Solutions , Staphylococcus aureus , X-Ray Diffraction

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http://hdl.handle.net/11693/25569

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http://dx.doi.org/10.1016/j.colsurfb.2014.04.006

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Institute of Materials Science and Nanotechnology (UNAM)