Zeta potential: A surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells

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buir.contributor.authorÖzbay, Ekmel
buir.contributor.orcidÖzbay, Ekmel|0000-0003-2953-1828
dc.citation.epage328en_US
dc.citation.issueNumber2en_US
dc.citation.spage321en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorZhang, Y.en_US
dc.contributor.authorYang, M.en_US
dc.contributor.authorPortney, N. G.en_US
dc.contributor.authorCui, D.en_US
dc.contributor.authorBudak, G.en_US
dc.contributor.authorÖzbay, Ekmelen_US
dc.contributor.authorOzkan, M.en_US
dc.contributor.authorOzkan, C. S.en_US
dc.date.accessioned2016-02-08T10:09:29Z
dc.date.available2016-02-08T10:09:29Z
dc.date.issued2008en_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentDepartment of Physicsen_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractWe demonstrate the use of surface Zeta potential measurements as a new tool to investigate the interactions of iron oxide nanoparticles and cowpea mosaic virus (CPMV) nanoparticles with human normal breast epithelial cells (MCF10A) and cancer breast epithelial cells (MCF7) respectively. A substantial understanding in the interaction of nanoparticles with normal and cancer cells in vitro will enable the capabilities of improving diagnostic and treatment methods in cancer research, such as imaging and targeted drug delivery. A theoretical Zeta potential model is first established to show the effects of binding process and internalization process during the nanoparticle uptake by cells and the possible trends of Zeta potential change is predicted for different cell endocytosis capacities. The corresponding changes of total surface charge of cells in the form of Zeta potential measurements were then reported after incubated respectively with iron oxide nanoparticles and CPMV nanoparticles. As observed, after MCF7 and MCF10A cells were incubated respectively with two types of nanoparticles, the significant differences in their surface charge change indicate the potential role of Zeta potential as a valuable biological signature in studying the cellular interaction of nanoparticles, as well as specific cell functionality.en_US
dc.identifier.doi10.1007/s10544-007-9139-2en_US
dc.identifier.eissn1572-8781
dc.identifier.issn1387-2176
dc.identifier.urihttp://hdl.handle.net/11693/23143
dc.language.isoEnglishen_US
dc.publisherSpringer New York LLCen_US
dc.relation.isversionofhttp://doi.org/10.1007/s10544-007-9139-2en_US
dc.source.titleBiomedical Microdevicesen_US
dc.subjectZeta potentialen_US
dc.subjectNormal breast cellsen_US
dc.subjectCancer breast cellsen_US
dc.subjectSurface chargeen_US
dc.subjectIron oxide nanoparticlesen_US
dc.subjectCPMV nanoparticlesen_US
dc.subjectCell endocytosisen_US
dc.titleZeta potential: A surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cellsen_US
dc.typeArticleen_US

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Department of Electrical and Electronics Engineering
Department of Physics
Institute of Materials Science and Nanotechnology (UNAM)
Nanotechnology Research Center (NANOTAM)