Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges

Date
2016
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Source Title
Lab on a Chip
Print ISSN
1473-0197
Electronic ISSN
1473-0189
Publisher
Royal Society of Chemistry
Volume
16
Issue
14
Pages
2572 - 2595
Language
English
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Abstract

This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems. On-chip and microfluidics combined devices along with optical microresonators provide rapid, robust, reproducible and multiplexed biodetection abilities in considerably small volumes. We present a detailed overview of the studies conducted so far, including biodetection of various oligonucleotide biomarkers as well as deoxyribonucleic acids (DNAs), ribonucleic acids (RNAs) and proteins. We particularly advert to chemical surface modifications for specific and selective biosensing.

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Published Version (Please cite this version)