Molecular analysis of enginereed nanomaterials in biomedical and regenerative medicine applications
buir.advisor | Elbüken, Çağlar | |
dc.contributor.author | Gündüz, Nuray | |
dc.date.accessioned | 2019-05-31T06:46:31Z | |
dc.date.available | 2019-05-31T06:46:31Z | |
dc.date.copyright | 2019-04 | |
dc.date.issued | 2019-04 | |
dc.date.submitted | 2019-05-29 | |
dc.description | Cataloged from PDF version of article. | en_US |
dc.description | Thesis (Ph.D.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2019. | en_US |
dc.description | Includes bibliographical references (leaves 110-118). | en_US |
dc.description.abstract | Molecular mechanisms are inspiration source for effective nanomaterial synthesis through minimalist bottom-up approaches. Mimicking functional biophysicochemical properties of biomacromolecules can give new insights for design and synthesis of nanomaterials used in biomedical and regenerative medicine applications. In this thesis, rationally-designed nanomaterials and their biomedical applications as oral ketone delivery and biomineralization and long-term potential toxicities were investigated. In the first chapter, basic concepts of nanomaterial design, synthesis, characterization, and nano-bio interface were explained. In the second chapter, a novel long-term nanoparticle accumulation model was developed to understand active regulation of nanoparticle uptake, nanoparticle accumulation behavior and the impact of long-term exposure on cellular machineries (e.g. ER stress). In the third chapter, the role of ketone body betahydroxybutryrate (βOHB) generated by a metabolic enzyme, hydroxymethylglutaryl CoA synthase 2 (HMGCS2), on intestinal stem cell maintenance and regeneration after radiation injury was investigated. Consequences of βOHB depletion in intestine were rectified by oral delivery of PLGA-encapsulated and oligomer forms of βOHB. The last chapter, acidic epitopes of enamel proteins (e.g. amelogenin) were integrated into self-assembling peptides to remineralize eroded enamel. Overall these studies show potential of natureinspired engineered nanomaterials in vast range of biomedical and regenerative medicine applications. | en_US |
dc.description.provenance | Submitted by Betül Özen (ozen@bilkent.edu.tr) on 2019-05-31T06:46:31Z No. of bitstreams: 1 NurayGunduz_PhD_Thesis.pdf: 11688918 bytes, checksum: 90fd61bc138ba349b70a835ad0dd9d5d (MD5) | en |
dc.description.provenance | Made available in DSpace on 2019-05-31T06:46:31Z (GMT). No. of bitstreams: 1 NurayGunduz_PhD_Thesis.pdf: 11688918 bytes, checksum: 90fd61bc138ba349b70a835ad0dd9d5d (MD5) Previous issue date: 2019-05 | en |
dc.description.statementofresponsibility | by Nuray Gündüz | en_US |
dc.embargo.release | 2019-11-29 | |
dc.format.extent | xx, 121 leaves : illustrations (some color), charts (some color) ; 30 cm. | en_US |
dc.identifier.itemid | B156418 | |
dc.identifier.uri | http://hdl.handle.net/11693/51971 | |
dc.language.iso | English | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Nanoparticle; toxicity | en_US |
dc.subject | Cell-nanomaterial interactions | en_US |
dc.subject | Gold nanoparticles; nanoparticle accumulation | en_US |
dc.subject | Organoid | en_US |
dc.subject | HMGCS2 | en_US |
dc.subject | Beta hydroxybutyrate | en_US |
dc.subject | Small intestine | en_US |
dc.subject | Oral ketone delivery | en_US |
dc.subject | Mineralization | en_US |
dc.subject | Enamel | en_US |
dc.subject | Self-assembling peptide | en_US |
dc.title | Molecular analysis of enginereed nanomaterials in biomedical and regenerative medicine applications | en_US |
dc.title.alternative | Biyomedikal ve yenileyici tıp uygulamalarında kullanılan nanomalzemelerin moleküler seviyede incelenmesi | en_US |
dc.type | Thesis | en_US |
thesis.degree.discipline | Materials Science and Nanotechnology | |
thesis.degree.grantor | Bilkent University | |
thesis.degree.level | Doctoral | |
thesis.degree.name | Ph.D. (Doctor of Philosophy) |
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