Zebrafish aging models and possible interventions

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buir.contributor.authorBirand, Dilan Ç.
buir.contributor.authorErbaba, Begün
buir.contributor.authorÖzdemir, Ahmet T.
buir.contributor.authorKafalıgönül, Hulusi
buir.contributor.authorAdams, Michelle
dc.citation.epage26en_US
dc.citation.spage3en_US
dc.contributor.authorBirand, Dilan Ç.en_US
dc.contributor.authorErbaba, Begünen_US
dc.contributor.authorÖzdemir, Ahmet T.en_US
dc.contributor.authorKafalıgönül, Hulusien_US
dc.contributor.authorAdams, Michelleen_US
dc.contributor.editorBozkurt, Y.
dc.date.accessioned2019-05-30T13:33:59Z
dc.date.available2019-05-30T13:33:59Z
dc.date.issued2018en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentDepartment of Psychologyen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.descriptionChapter 1en_US
dc.description.abstractAcross the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the lifespan increases, there will be a need for maintaining a healthy state for these individuals. Our current knowledge on types and durations of potential anti-aging therapies is quite limited. Recently the zebrafish has emerged as a promising model for understanding the cognitive and neurobiological changes during aging, as well as its use with potential anti-aging interventions. Like humans this model organism ages gradually, displays similar behavioral properties and social characteristics, and in addition, there is a wealth of molecular and genetic tools to uncover the cellular mechanism that contribute to age-related cognitive declines. Drug effect and toxicity can be easily tested in the zebrafish. Therefore, this animal model can provide information about potential therapies that could be translated directly into human populations or provide a more focused treatment direction for testing in other mammalian animal models. The zebrafish will be a powerful tool for uncovering the mysteries of the aging brain.en_US
dc.identifier.doi10.5772/intechopen.75554en_US
dc.identifier.isbn9781789231724
dc.identifier.urihttp://hdl.handle.net/11693/51967
dc.language.isoEnglishen_US
dc.publisherInTechOpen Pressen_US
dc.relation.ispartofRecent advances in zebrafish researchesen_US
dc.relation.isversionofhttp://dx.doi.org/10.5772/intechopen.75554en_US
dc.subjectAgingen_US
dc.subjectBehavioren_US
dc.subjectNeurobiologyen_US
dc.subjectDietary regimensen_US
dc.subjectRapamycinen_US
dc.subjectMorpholinoen_US
dc.subjectZebrafish aging modelsen_US
dc.titleZebrafish aging models and possible interventionsen_US
dc.typeBook Chapteren_US

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Department of Molecular Biology and Genetics
Aysel Sabuncu Brain Research Center (BAM)
Department of Psychology
Institute of Materials Science and Nanotechnology (UNAM)
National Magnetic Resonance Research Center (UMRAM)