Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging

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buir.contributor.authorDemir, Hilmi Volkan
buir.contributor.orcidDemir, Hilmi Volkan|0000-0003-1793-112X
dc.citation.epage4966en_US
dc.citation.issueNumber23en_US
dc.citation.spage4961en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorSharma, V. K.en_US
dc.contributor.authorGokyar, S.en_US
dc.contributor.authorKelestemur, Y.en_US
dc.contributor.authorErdem, T.en_US
dc.contributor.authorUnal, E.en_US
dc.contributor.authorDemir, Hilmi Volkanen_US
dc.date.accessioned2015-07-28T12:01:41Z
dc.date.available2015-07-28T12:01:41Z
dc.date.issued2014en_US
dc.departmentDepartment of Physicsen_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractIn this work, dual-modal (fluorescence and magnetic resonance) imaging capabilities of water-soluble, low-toxicity, monodisperse Mn-doped ZnSe nanocrystals (NCs) with a size (6.5 nm) below the optimum kidney cutoff limit (10 nm) are reported. Synthesizing Mn-doped ZnSe NCs with varying Mn2+ concentrations, a systematic investigation of the optical properties of these NCs by using photoluminescence (PL) and time resolved fluorescence are demonstrated. The elemental properties of these NCs using X-ray photoelectron spectroscopy and inductive coupled plasma-mass spectroscopy confirming Mn2+ doping is confined to the core of these NCs are also presented. It is observed that with increasing Mn2+ concentration the PL intensity first increases, reaching a maximum at Mn2+ concentration of 3.2 at% (achieving a PL quantum yield (QY) of 37%), after which it starts to decrease. Here, this high-efficiency sample is demonstrated for applications in dual-modal imaging. These NCs are further made water-soluble by ligand exchange using 3-mercaptopropionic acid, preserving their PL QY as high as 18%. At the same time, these NCs exhibit high relaxivity (≈2.95 mM-1 s-1) to obtain MR contrast at 25°C, 3 T. Therefore, the Mn2+ doping in these water-soluble Cd-free NCs are sufficient to produce contrast for both fluorescence and magnetic resonance imaging techniques.en_US
dc.identifier.doi10.1002/smll.201401143en_US
dc.identifier.eissn1613-6829
dc.identifier.issn1613-6810
dc.identifier.urihttp://hdl.handle.net/11693/12486
dc.language.isoEnglishen_US
dc.publisherWiley-VCH Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/smll.201401143en_US
dc.source.titleSmallen_US
dc.subjectFluorescence Imagingen_US
dc.subjectLow-toxicityen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectNanocrystalsen_US
dc.subjectWater-solubilityen_US
dc.titleManganese doped fluorescent paramagnetic nanocrystals for dual-modal imagingen_US
dc.typeArticleen_US

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Department of Physics
Department of Electrical and Electronics Engineering
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