Robustness and delay margin analysis of a gene regulatory network model

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buir.contributor.authorÖztürk, Dilan
buir.contributor.authorÖzbay, Hitay
buir.contributor.authorAtay, Fatihcan M.
buir.contributor.orcidÖztürk, Dilan|0000-0001-7821-7160
buir.contributor.orcidÖzbay, Hitay|0000-0003-1134-0679
buir.contributor.orcidAtay, Fatihcan M.|0000-0001-6277-6830
dc.citation.epage258en_US
dc.citation.issueNumber25en_US
dc.citation.spage253en_US
dc.citation.volumeNumber55en_US
dc.contributor.authorÖztürk, Dilan
dc.contributor.authorÖzbay, Hitay
dc.contributor.authorAtay, Fatihcan M.
dc.date.accessioned2023-02-23T11:30:42Z
dc.date.available2023-02-23T11:30:42Z
dc.date.issued2022-10-10
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentDepartment of Mathematicsen_US
dc.description.abstractIn the past, a special type of nonlinear delay differential system structure was proposed for gene regulatory networks. For this cyclic dynamical system, stability analysis was done using various tools from systems theory. This paper investigates robust stability of an extended gene regulatory network model with time delayed negative feedback. Specifically, the delay margin analysis is done for this system under multiplicative uncertainty. The effect of uncertainty on the delay margin is determined. It is also shown that for particular higher order extensions of the model it is possible to improve the delay margin.en_US
dc.identifier.doi10.1016/j.ifacol.2022.09.355en_US
dc.identifier.eissn2405-8963
dc.identifier.urihttp://hdl.handle.net/11693/111628
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://dx.doi.org/en_US
dc.source.titleIFAC-PapersOnlineen_US
dc.subjectGene regulatory networksen_US
dc.subjectRobustness analysisen_US
dc.subjectSystems with time-delaysen_US
dc.subjectRobust time-delay systemsen_US
dc.titleRobustness and delay margin analysis of a gene regulatory network modelen_US
dc.typeArticleen_US

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