Robustness and delay margin analysis of a gene regulatory network model

Date
2022-10-10
Advisor
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Source Title
IFAC-PapersOnline
Print ISSN
Electronic ISSN
2405-8963
Publisher
Elsevier
Volume
55
Issue
25
Pages
253 - 258
Language
English
Type
Article
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Abstract

In the past, a special type of nonlinear delay differential system structure was proposed for gene regulatory networks. For this cyclic dynamical system, stability analysis was done using various tools from systems theory. This paper investigates robust stability of an extended gene regulatory network model with time delayed negative feedback. Specifically, the delay margin analysis is done for this system under multiplicative uncertainty. The effect of uncertainty on the delay margin is determined. It is also shown that for particular higher order extensions of the model it is possible to improve the delay margin.

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Keywords
Gene regulatory networks, Robustness analysis, Systems with time-delays, Robust time-delay systems
Citation
Published Version (Please cite this version)