Development of a thulium (Tm:YAP) laser system for brain tissue ablation

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dc.citation.epage706en_US
dc.citation.issueNumber5en_US
dc.citation.spage699en_US
dc.citation.volumeNumber26en_US
dc.contributor.authorBilici, T.en_US
dc.contributor.authorMutlu, S.en_US
dc.contributor.authorKalaycioglu H.en_US
dc.contributor.authorKurt, A.en_US
dc.contributor.authorSennaroglu, A.en_US
dc.contributor.authorGulsoy, M.en_US
dc.date.accessioned2016-02-08T09:51:05Z
dc.date.available2016-02-08T09:51:05Z
dc.date.issued2011en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractIn this study, a thulium (Tm:YAP) laser system was developed for brain surgery applications. As the Tm:YAP laser is a continuous-wave laser delivered via silica fibers, it would have great potential for stereotaxic neurosurgery with highest local absorption in the IR region. The laser system developed in this study allowed the user to set the power level, exposure time, and modulation parameters (pulse width and on-off cycles). The Tm:YAP laser beam (200-600 mW, 69-208 W/cm 2) was delivered from a distance of 2 mm to cortical and subcortical regions of ex-vivo Wistar rat brain tissue samples via a 200-μm-core optical fiber. The system performance, dosimetry study, and ablation characteristics of the Tm:YAP laser were tested at different power levels by maximizing the therapeutic effects and minimizing unwanted thermal side-effects. The coagulation and ablation diameters were measured under microscope. The maximum ablation efficiency (100 × ablation diameter/coagulation diameter) was obtained when the Tm:YAP laser system was operated at 200 mW for 10 s. At this laser dose, the ablation efficiency was found to be 71.4% and 58.7% for cortical and subcortical regions, respectively. The fiber-coupled Tm:YAP laser system in hence proposed for the delivery of photothermal therapies in medical applications. © 2011 Springer-Verlag London Ltd.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T09:51:05Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2011en
dc.identifier.doi10.1007/s10103-011-0915-0en_US
dc.identifier.issn0268-8921
dc.identifier.urihttp://hdl.handle.net/11693/21783
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s10103-011-0915-0en_US
dc.source.titleLasers in Medical Scienceen_US
dc.subject1980-nmen_US
dc.subjectAblation efficiencyen_US
dc.subjectBrain tissue ablationen_US
dc.subjectThulium laseren_US
dc.subjectglass fiberen_US
dc.subjectsilicon dioxideen_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectbrain cortexen_US
dc.subjectbrain surgeryen_US
dc.subjectbrain tissueen_US
dc.subjectbrain tissue ablationen_US
dc.subjectcontrolled studyen_US
dc.subjectdosimetryen_US
dc.subjectex vivo studyen_US
dc.subjectgray matteren_US
dc.subjectinfrared radiationen_US
dc.subjectlaseren_US
dc.subjectmicroscopeen_US
dc.subjectnonhumanen_US
dc.subjecton off cycleen_US
dc.subjectphototherapyen_US
dc.subjectphysical parametersen_US
dc.subjectpower levelen_US
dc.subjectpriority journalen_US
dc.subjectprocess optimizationen_US
dc.subjectpulse widthen_US
dc.subjectradiation absorptionen_US
dc.subjectradiation doseen_US
dc.subjectradiation exposureen_US
dc.subjectraten_US
dc.subjectstereotaxic surgeryen_US
dc.subjectsubcortexen_US
dc.subjectthermocoagulationen_US
dc.subjectthulium yttrium aluminum perovskite laseren_US
dc.subjectwhite matteren_US
dc.subjectAnimalsen_US
dc.subjectBrainen_US
dc.subjectLaser Therapyen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectThuliumen_US
dc.titleDevelopment of a thulium (Tm:YAP) laser system for brain tissue ablationen_US
dc.typeArticleen_US

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