Fast-dissolving electrospun nanofibrous films of paracetamol/cyclodextrin inclusion complexes

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buir.contributor.authorYıldız, Zehra İrem
buir.contributor.authorUyar, Tamer
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481
dc.citation.epage633en_US
dc.citation.spage626en_US
dc.citation.volumeNumber492en_US
dc.contributor.authorYıldız, Zehra İremen_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2020-01-27T12:21:42Z
dc.date.available2020-01-27T12:21:42Z
dc.date.issued2019
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractThe free-standing and fast-dissolving nanofibrous films from inclusion complexes (ICs) of paracetamol with two different cyclodextrins, hydroxypropyl-beta-cyclodextrin (HPβCD) and sulfobutylether-beta-cyclodextrin (SBEβ-CD) were produced through electrospinning without using polymer matrix. The morphology of the nanofibers (NFs) was uniform and bead-free as confirmed by scanning electron microscopy imaging. The chemical, structural and thermal characteristics of the electrospun paracetamol/CD-IC NFs were investigated by X-ray diffractometry, Fourier transform infrared spectroscopy, differential scanning calorimetry, thermal gravimetric analyzer and proton nuclear magnetic resonance. The aforementioned methods indicated the successful formation of ICs of paracetamol with both CD types (HPβCD and SBE-β-CD). Besides, paracetamol/CD-IC NFs exhibited different features and properties from pristine paracetamol. For instance, the crystalline state of pristine paracetamol was transformed into amorphous state by CD-IC NFs formation which is important for the water-solubility increment of the drug molecules. Moreover, thermal studies indicated that paracetamol became thermally more stable in CD-IC NFs. The molar ratio of paracetamol:CD was found as ~0.85:1.00 for paracetamol/HPβCD-IC NFs and ~0.80:1.00 for paracetamol/SBE-β-CD-IC NFs. The dissolution behavior of paracetamol/CD-IC nanofibrous films was examined by exposing them to water. The electrospun paracetamol/CD-IC nanofibrous films showed fast-dissolving character in water due to the CD-ICs formation and high surface area of nanofibrous structure.en_US
dc.embargo.release2021-10-30
dc.identifier.doi10.1016/j.apsusc.2019.06.220en_US
dc.identifier.issn0169-4332
dc.identifier.urihttp://hdl.handle.net/11693/52841
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://dx.doi.org/10.1016/j.apsusc.2019.06.220en_US
dc.source.titleApplied Surface Scienceen_US
dc.subjectParacetamolen_US
dc.subjectCyclodextrin inclusion complexesen_US
dc.subjectElectrospinningen_US
dc.subjectNanofibersen_US
dc.subjectFast-dissolvingen_US
dc.titleFast-dissolving electrospun nanofibrous films of paracetamol/cyclodextrin inclusion complexesen_US
dc.typeArticleen_US

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