p53 mutations as fingerprints of environmental carcinogens

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dc.citation.epage999en_US
dc.citation.issueNumber6en_US
dc.citation.spage995en_US
dc.citation.volumeNumber72en_US
dc.contributor.authorCetin-Atalay, R.en_US
dc.contributor.authorOzturk, M.en_US
dc.date.accessioned2016-02-08T11:58:29Z
dc.date.available2016-02-08T11:58:29Z
dc.date.issued2000en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractMutations of the p53 tumor suppressor gene occur in a great majority of human cancers. The protein product of p53 gene is involved in DNA damage response. Consequently, p53 gene may be a preferred target for environmental carcinogens, which also act as DNA-damaging agents. This is probably why p53 mutations are frequent in cancers linked to environmental carcinogens. Moreover, these carcinogens leave molecular fingerprints on the p53 gene. Thus, the study of p53 mutation spectra has been a useful approach to implicate suspected carcinogens to different human cancers. This review provides further insight into the significance of p53 mutation spectra in ten common human malignancies (skin, liver, lung, bladder, breast, head and neck, esophagus, stomach and colorectal cancers, and hematological malignancies), in relation with environmental carcinogens.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T11:58:29Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2000en
dc.identifier.issn0033-4545
dc.identifier.urihttp://hdl.handle.net/11693/27635
dc.language.isoEnglishen_US
dc.source.titlePure and Applied Chemistryen_US
dc.subjectCarcinogenen_US
dc.subjectProtein p53en_US
dc.subjectBladder canceren_US
dc.subjectBlood diseaseen_US
dc.subjectBreast canceren_US
dc.subjectCanceren_US
dc.subjectColorectal canceren_US
dc.subjectConference paperen_US
dc.subjectDNA damageen_US
dc.subjectDNA fingerprintingen_US
dc.subjectEnvironmental exposureen_US
dc.subjectEsophagus canceren_US
dc.titlep53 mutations as fingerprints of environmental carcinogensen_US
dc.typeArticleen_US

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