p53 mutations as fingerprints of environmental carcinogens

Date
2000
Authors
Cetin-Atalay, R.
Ozturk, M.
Advisor
Instructor
Source Title
Pure and Applied Chemistry
Print ISSN
0033-4545
Electronic ISSN
Publisher
Volume
72
Issue
6
Pages
995 - 999
Language
English
Type
Article
Journal Title
Journal ISSN
Volume Title
Abstract

Mutations of the p53 tumor suppressor gene occur in a great majority of human cancers. The protein product of p53 gene is involved in DNA damage response. Consequently, p53 gene may be a preferred target for environmental carcinogens, which also act as DNA-damaging agents. This is probably why p53 mutations are frequent in cancers linked to environmental carcinogens. Moreover, these carcinogens leave molecular fingerprints on the p53 gene. Thus, the study of p53 mutation spectra has been a useful approach to implicate suspected carcinogens to different human cancers. This review provides further insight into the significance of p53 mutation spectra in ten common human malignancies (skin, liver, lung, bladder, breast, head and neck, esophagus, stomach and colorectal cancers, and hematological malignancies), in relation with environmental carcinogens.

Course
Other identifiers
Book Title
Keywords
Carcinogen, Protein p53, Bladder cancer, Blood disease, Breast cancer, Cancer, Colorectal cancer, Conference paper, DNA damage, DNA fingerprinting, Environmental exposure, Esophagus cancer
Citation
Published Version (Please cite this version)