Membrane-mediated interactions between disk-like inclusions adsorbed on vesicles

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buir.contributor.authorAlizadeh-Haghighi, Elnaz
buir.contributor.authorKaraei Shiraz, Arash
buir.contributor.authorBahrami, Amir Houshang
buir.contributor.orcidBahrami, Amir Houshang|0000-0001-5841-2516
dc.citation.epage10en_US
dc.citation.spage1en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorAlizadeh-Haghighi, Elnaz
dc.contributor.authorKaraei Shiraz, Arash
dc.contributor.authorBahrami, Amir Houshang
dc.date.accessioned2023-02-28T09:58:32Z
dc.date.available2023-02-28T09:58:32Z
dc.date.issued2022-10-17
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.description.abstractSelf-assembly of membrane inclusions plays a key role in biological processes such as cellular signalling and trafficking and has potential applications for designing interfacial devices such as sensors and actuators. Despite intensive studies of curvature-mediated interactions, how membrane curvature modulates interactions between flat disk-like inclusions, adsorbed on vesicles, remains unknown. We use Monte Carlo simulations of a triangulated vesicle with simulated annealing to explore curvature-mediated interactions between disk-like rigid inclusions, induced by membrane elastic energy. We distinguish two distinct short and long-range curvature-mediated interactions for disk distances below and above the vesicle diameter. We observe short-range neutral interactions in the limit of small disks, where the vesicle appears as a flat bilayer to the disks. Beyond a certain size of disk-like inclusions, we find a transition from neutral to attractive short-range forces. Consistent with experiments, we also show that upon deflating vesicles, previously-attracted disks experience repulsive interactions. Our findings show how the vesicle curvature and the relative size between the disks and the vesicle determine the character of membrane-mediated interactions between adsorbed disk-like inclusions. Copyright © 2022 Alizadeh-Haghighi, Karaei Shiraz and Bahrami.en_US
dc.description.provenanceSubmitted by Cem Çağatay Akgün (cem.akgun@bilkent.edu.tr) on 2023-02-28T09:58:32Z No. of bitstreams: 1 Membrane-mediated_interactions_between_disk-like_inclusions_adsorbed_on_vesicles.pdf: 3799664 bytes, checksum: 7ce92f215a8bd0060ff91fa34749e11d (MD5)en
dc.description.provenanceMade available in DSpace on 2023-02-28T09:58:32Z (GMT). No. of bitstreams: 1 Membrane-mediated_interactions_between_disk-like_inclusions_adsorbed_on_vesicles.pdf: 3799664 bytes, checksum: 7ce92f215a8bd0060ff91fa34749e11d (MD5) Previous issue date: 2022-10-17en
dc.identifier.doi10.3389/fphy.2022.1020619en_US
dc.identifier.issn2296424X
dc.identifier.urihttp://hdl.handle.net/11693/111895
dc.language.isoEnglishen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isversionofhttps://dx.doi.org/10.3389/fphy.2022.1020619en_US
dc.source.titleFrontiers in Physicsen_US
dc.subjectElastic energyen_US
dc.subjectMembrane curvatureen_US
dc.subjectMonte carlo simulationsen_US
dc.subjectPairwise interactionsen_US
dc.subjectRigid disksen_US
dc.subjectSimulated annealingen_US
dc.subjectVesicleen_US
dc.titleMembrane-mediated interactions between disk-like inclusions adsorbed on vesiclesen_US
dc.typeArticleen_US

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