Orally fast disintegrating cyclodextrin/prednisolone inclusion-complex nanofibrous webs for potential steroid medications

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buir.contributor.authorDurgun, Engin
buir.contributor.orcidDurgun, Engin|0000-0002-0639-5862
dc.citation.epage4500en_US
dc.citation.issueNumber12en_US
dc.citation.spage4486en_US
dc.citation.volumeNumber18en_US
dc.contributor.authorÇelebioğlu, A.
dc.contributor.authorWang, N.
dc.contributor.authorKılıç, M. E.
dc.contributor.authorDurgun, Engin
dc.contributor.authorUyar, T.
dc.date.accessioned2022-01-25T12:10:00Z
dc.date.available2022-01-25T12:10:00Z
dc.date.issued2021-12-06
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractPrednisolone is a widely used immunosuppressive and anti-inflammatory drug type that suffers from low aqueous solubility and bioavailability. Due to the inclusion complexation with cyclodextrins (CDs), prednisolone’s drawbacks that hinder its potential during the administration can be eliminated effectively. Here, we have early shown the electrospinning of free-standing nanofibrous webs of CD/prednisolone inclusion complexes (ICs) in the absence of a polymer matrix. In this study, hydroxypropyl-beta-CD (HPβCD) has been used to form ICs with prednisolone and generate nanofibrous webs with a drug loading capacity of ∼10% (w/w). Pullulan/prednisolone nanofibrous webs have been also fabricated as a control sample having the same drug loading (∼10%, w/w). It has been demonstrated that prednisolone has been found in an amorphous state in the HPβCD/prednisolone nanofibrous web due to inclusion complexation, while it has retained its crystal structure in the pullulan/prednisolone nanofibrous web. Therefore, the HPβCD/prednisolone IC nanofibrous web has shown a faster and enhanced release profile and superior disintegration feature in artificial saliva than the pullulan/prednisolone nanofibrous web. The complexation energy calculated using ab initio modeling displayed a more favorable interaction between HPβCD and prednisolone in the case of a molar ratio of 2:1 than 1:1 (CD: drug). Here, the HPβCD/prednisolone IC nanofibrous web has been developed without using a toxic component or solvent to dissolve drug molecules and boost drug loading in amorphous nature. The investigation of IC nanofibrous webs has been conducted to formulate a promising alternative to the orally disintegrating tablet formulation of prednisolone in the market. The nanofibrous structure and the improved physicochemical properties of prednisolone arising with the complexation might ensure a faster disintegration and onset of action against commercially available and orally disintegrating delivery systems during the desired treatment.en_US
dc.description.provenanceSubmitted by Mustafa Er (mer@bilkent.edu.tr) on 2022-01-25T12:10:00Z No. of bitstreams: 1 Orally_fast_disintegrating_cyclodextrinprednisolone_inclusion-complex_nanofibrous_webs_for_potential_steroid_medications.pdf: 12008712 bytes, checksum: 622075cf591dee14e953693ef2ccd166 (MD5)en
dc.description.provenanceMade available in DSpace on 2022-01-25T12:10:00Z (GMT). No. of bitstreams: 1 Orally_fast_disintegrating_cyclodextrinprednisolone_inclusion-complex_nanofibrous_webs_for_potential_steroid_medications.pdf: 12008712 bytes, checksum: 622075cf591dee14e953693ef2ccd166 (MD5) Previous issue date: 2021-12-06en
dc.identifier.doi10.1021/acs.molpharmaceut.1c00677en_US
dc.identifier.eissn1543-8392
dc.identifier.issn1543-8384
dc.identifier.urihttp://hdl.handle.net/11693/76778
dc.language.isoEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttps://doi.org/10.1021/acs.molpharmaceut.1c00677en_US
dc.source.titleMolecular Pharmaceuticsen_US
dc.subjectCyclodextrinen_US
dc.subjectElectrospinningen_US
dc.subjectPrednisoloneen_US
dc.subjectInclusion complexen_US
dc.subjectFast disintegratingen_US
dc.subjectOral drug deliveryen_US
dc.titleOrally fast disintegrating cyclodextrin/prednisolone inclusion-complex nanofibrous webs for potential steroid medicationsen_US
dc.typeArticleen_US

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