Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes α7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons

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dc.citation.epage14854en_US
dc.citation.issueNumber47en_US
dc.citation.spage14847en_US
dc.citation.volumeNumber29en_US
dc.contributor.authorHruska, M.en_US
dc.contributor.authorKeefe J.en_US
dc.contributor.authorWert, D.en_US
dc.contributor.authorTekinay, A.B.en_US
dc.contributor.authorHulce J.J.en_US
dc.contributor.authorIbañez-Tallon I.en_US
dc.contributor.authorNishi, R.en_US
dc.date.accessioned2016-02-08T10:01:45Z
dc.date.available2016-02-08T10:01:45Z
dc.date.issued2009en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractVertebrate α-bungarotoxin-like molecules of the Ly-6 superfamily have been implicated as balancers of activity and survival in the adult nervous system. To determine whether a member of this family could be involved in the development of the avian ciliary ganglion, we identified 6 Gallus genes by their homology in structure to mouse lynx1 and lynx2. One of these genes, an ortholog of prostate stem cell antigen (psca), is barely detectable at embryonic day (E) 8, before neuronal cell loss in the ciliary ganglion, but increases > 100-fold as the number of neurons begins to decline between E9 and E14. PSCA is highly expressed in chicken and mouse telencephalon and peripheral ganglia and correlates with expression of α7-containing nicotinic acetylcholine receptors (α7-nAChRs). Misexpressing PSCA before cell death in the ciliary ganglion blocks α7-nAChR activation by nicotine and rescues the choroid subpopulation from dying. Thus, PSCA, a molecule previously identified as a marker of prostate cancer, is a member of the Ly-6 neurotoxin-like family in the nervous system, and is likely to play a role as a modulator of α7 signaling-induced cell death during development. Copyright © 2009 Society for Neuroscience.en_US
dc.description.provenanceMade available in DSpace on 2016-02-08T10:01:45Z (GMT). No. of bitstreams: 1 bilkent-research-paper.pdf: 70227 bytes, checksum: 26e812c6f5156f83f0e77b261a471b5a (MD5) Previous issue date: 2009en
dc.identifier.doi10.1523/JNEUROSCI.2271-09.2009en_US
dc.identifier.issn0270-6474
dc.identifier.urihttp://hdl.handle.net/11693/22562
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1523/JNEUROSCI.2271-09.2009en_US
dc.source.titleJournal of Neuroscienceen_US
dc.subjectalpha bungarotoxinen_US
dc.subjectbungarotoxin receptoren_US
dc.subjectcomplementary DNAen_US
dc.subjectneurotoxinen_US
dc.subjectprostate stem cell antigenen_US
dc.subjectRNAen_US
dc.subjectvirus vectoren_US
dc.subjectanimal tissueen_US
dc.subjectapoptosisen_US
dc.subjectarticleen_US
dc.subjectchick embryoen_US
dc.subjectciliary ganglionen_US
dc.subjectcontrolled studyen_US
dc.subjectembryo developmenten_US
dc.subjectgene expressionen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmouseen_US
dc.subjectnerve cell necrosisen_US
dc.subjectnervous system developmenten_US
dc.subjectnonhumanen_US
dc.subjectparasympathetic nerve cellen_US
dc.subjectpriority journalen_US
dc.subjectprostate canceren_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjecttelencephalonen_US
dc.subjectAmino Acid Sequenceen_US
dc.subjectAnimalsen_US
dc.subjectApoptosisen_US
dc.subjectAvian Proteinsen_US
dc.subjectBase Sequenceen_US
dc.subjectChickensen_US
dc.subjectGanglia, Parasympatheticen_US
dc.subjectGene Expression Regulation, Developmentalen_US
dc.subjectMembrane Glycoproteinsen_US
dc.subjectMiceen_US
dc.subjectMolecular Sequence Dataen_US
dc.subjectNeoplasm Proteinsen_US
dc.subjectNeuronsen_US
dc.subjectNeuropeptidesen_US
dc.subjectNeurotoxinsen_US
dc.subjectNicotinic Agonistsen_US
dc.subjectNicotinic Antagonistsen_US
dc.subjectReceptors, Nicotinicen_US
dc.subjectSequence Homology, Nucleic Aciden_US
dc.subjectTelencephalonen_US
dc.titleProstate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes α7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neuronsen_US
dc.typeArticleen_US

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